Meta-Analysis
Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Jun 28, 2014; 20(24): 7971-7978
Published online Jun 28, 2014. doi: 10.3748/wjg.v20.i24.7971
Table 1 Baseline information of studies included in the meta-analysis
Ref.No. of HCC patientsNo. of controlsYear of studyCountry of study
Unitt et al[15]25482005United Kingdom
Ormandy et al[16]84212005Germany
Guo et al[17]22122006China
Fu et al[18]123472007China
Peng et al[21]63402007China
Yang et al[20]28262007China
Cao et al[19]33202007United States
Yu et al[22]58152008China
Zhang et al[23]100202008China
Huang et al[28]93242010China
Kuang et al[26]28262010China
Wang et al[27]46322010China
Yoshizawa et al[24]57312010Japan
Zhang et al[25]49252010China
Thakur et al[33]28152011Indian
1Fan et al[30]138-2011China
Liu et al[32]40282011China
Aleem et al[29]15102011Egypt
Feng et al[31]42152011China
Wang et al[34]30302011China
Yang et al[37]60202012China
Wu et al[36]78122012China
Chen et al[35]39302012China
Table 2 Summary of odds ratios and 95%CIs in this meta-analysis
ItemsOR
Heterogeneity
OR (95%CI)P valueQ2t2I2(%)P value
Ciculating populations of Tregs between HCC patients and health controls1.868 (1.489-2.344)0539.280.274196.10
Populations of Tregs in the tumor and surrounding tissues4.040 (2.094-7.794)0133.410.525097.00
Populations of Tregs in the tumor and the normal liver tissues2.869 (2.157-3.817)03.770.028246.90.152
Populations of Tregs among HCC patients with different tumor numbers (one tumor mass or more)1.670 (0.879-3.171)0.11794.910.313897.90
Populations of Tregs among HCC patients with different tumor sizes (smaller or larger than 5 cm)1.170 (0.844-1.620)0.346102.410.132596.10
6 Populations of Tregs between HCC patients with or without capsule1.073 (0.798-1.442)0.64261.480.068295.10
Populations of Tregs among HCC patients in different TNM stages (I/II vs III/IV)0.646 (0.207-2.021)0.453365.991.333899.20
Populations of Tregs between HCC patients with or without HBV infection1.189 (0.904-1.564)0.21645.020.085691.10
Populations of Tregs among HCC patients with different AFP levels (lower or higher than 20 ng/mL)1.458 (0.714-2.975)0.3143.210.391698.60