Value of MR diffusion imaging in hepatic fibrosis and its correlations with serum indices

Table 1 Serum values of hyaluronic acid, collagen type IV, type III procollagen, and laminin in different stages of liver fibrosis (mean ± SD)

Stage of liver fibrosis	Cases (n)	Serum indices
		HA (μg/L)	LN (μg/L)	PCIII (μg/L)	IV-C (μg/L)
Control	23	58.12 ± 13.51	96.67 ± 21.53	82.63 ± 11.74	57.54 ± 19.76
S0	13	62.72 ± 23.24	97.47 ± 23.41	87.23 ± 24.17	56.59 ± 21.29
S1	14	84.29 ± 32.96	111.89 ± 26.35	106.37 ± 25.45	61.70 ± 24.83
S2	9	145.46 ± 87.01	115.00 ± 43.14	117.41 ± 28.57	78.93 ± 46.37
S3	11	215.36 ± 96.08	128.64 ± 44.30	149.33 ± 37.11	99.65 ± 40.61
S4	7	300.05 ± 121.95	129.94 ± 36.36	168.17 ± 34.27	131.17 ± 52.51
F		25.62	2.699	20.24	8.102
P value		0.0000	0.0573	0.0000	0.0000

HA: Hyaluronic acid; LN: Laminin; PCIII: Type III procollagen; IV-C: Collagen type IV.

Table 2 Changes in b and apparent diffusion coefficient values in different stages of hepatic fibrosis (mean ± SD)

Stage of liver fibrosis	Cases (n)	ADC value (× 10-3 mm2/s)
		b1 = 300 s/mm2	b2 = 500 s/mm2	b3 =700 s/mm2
Control	23	1.80 ± 0.34	1.69 ± 0.39	1.51 ± 0.34
S0	13	1.93 ± 0.25	1.63 ± 0.19	1.49 ± 0.11
S1	14	1.83 ± 0.25	1.60 ± 0.17	1.43 ± 0.14
S2	9	1.71 ± 0.27	1.44 ± 0.18	1.26 ± 0.13
S3	11	1.79 ± 0.26	1.36 ± 0.17	1.20 ± 0.13
S4	7	1.39 ± 0.21	1.18 ± 0.16	1.15 ± 0.22
F		3.648	5.926	5.758
P		0.0054	0.0001	0.0002

ADC: Apparent diffusion coefficient.

Table 3 Correlation analysis of apparent diffusion coefficient and serum indices of liver fibrosis at different b values

Serum index	b1 = 300 s/mm2		b2 = 500 s/mm2		b3 = 700 s/mm2
	r value	P value	r value	P value	r value	P value
HA	-0.853	0.031	-0.991	0.000	-0.951	0.003
LN	-0.686	0.132	-0.926	0.008	-0.956	0.003
PCIII	-0.486	0.328	-0.976	0.001	-0.959	0.002
IV-C	-0.946	0.004	-0.981	0.001	-0.925	0.008

HA: Hyaluronic acid; LN: Laminin; PCIII: Type III procollagen; IV-C: Collagen type IV.