Human genes involved in hepatitis B virus infection

doi:10.3748/wjg.v20.i24.7696

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World J Gastroenterol. Jun 28, 2014; 20(24): 7696-7706
Published online Jun 28, 2014. doi: 10.3748/wjg.v20.i24.7696

Table 1 Genes associated with hepatitis B virus clearance and persistence

Associated with clearance or persistence	Ref.	Area/country	Population	Allele or haplotype	Frequency (%)		OR	P value	Comments
Associated with clearance or persistence	Ref.	Area/country	Population	Allele or haplotype	Clearance/number	Persistence/number		P value	Comments
Clearance							OR
HLA	Thio et al[12]	United States	Caucasian	A*0301	15.7/342	8.1/194	0.47	0.0005	Several cohorts combined
	Thio et al[12]	United States	Caucasian	DRB1*1302	4.9/342	2.1/194	0.42	0.030	Limited power
	Thursz et al[18]	United Kingdom	Gambias	DRB1*1301	7.3/218 (children)	2.7/185 (children)	0.35	0.037	Class I serol typing
				DRB1*1302	26.6/218 (children)	16.2/185 (children)	0.53	0.012	Malaria cases unkown
				DRB1*1302	25.6/195	7.5/40	0.24	0.012
	Höhler et al[19]	Germany	German	DRB1*1301-02	33.3/24	5.7/70	0.12	0.004	Small sample size
	Höhler et al[19]	Germany	German	DRB1*1302	12.5/24	0/70		0.018
	Almarri et al[33]	Qatar	Qatarians	D2	26/31	14/21	0.10	0.013	Small numbers and HLA serol typing
	Wu et al[13]	Taiwan	Han Chinese	DR*0406	4.0/324	0.0/98	0.057	< 0.001
				DR*0701	3.1/324	0.5/98	0.18	0.042
				DR7	3.1/324	0.5/98	0.18	0.042
			Taiwanese Aborigines	B*4001	32.8/229	26.5/138	0.65	0.045
	Albayrak et al[14]	Turkey	Turks	CW1	26.67/30	5.33/75	6.455	< 0.05	Small sample size
	Albayrak et al[14]	Turkey	Turks	DR13	36.67/30	8.0/75	6.658	< 0.05
	Wong et al[26]	Hong Kong	Chinese	rs3077 T	27.6/259	20.7/500	1.41	0.0083
				rs9277378 A	34.0/259	24.2/500	1.61	0.83E-2
				rs3128917 T	44.6/259	33.5/500	1.54	1.1E-4
				Haplotype TAT	20.9/259	14.7/500	1.64	0.0013
	Ramenazi et al[16]	Iran	Iranian	DRB1*13	11.67/30	3.13/64	0.22	< 0.03	Small sample size
	Kamatani et al[21]	Japan	Japanese	HLA-DPA10103-DPB10402	9.6/2100	4.2/1300	0.52	6.00E-8
	Kamatani et al[21]	Japan	Japanese	HLA-DPA10103-DPB10401	3.8/2100	1.8/1300	0.57	0.002
	An et al[22]	United States	Chinese	HLA-DPA1 rs3077 (TT/TC/CC)	(14.0/56.0/30.0)/287	(9.0/40.0/51.0)/1218	2.41	3.47E-10
	An et al[22]	United States	Chinese	HLA-DPB1 rs9277535 (AA/AG/GG)	(61/100/63)/224	(252/546/395)/1193	0.81	0.036
	Nishida et al[29]	Japan	Japanese, Korean, Chinese, Thai	rs3077 T	18.6/564	8.3/751	0.46	4.40E-19	GWAS-meta-analysis
	Nishida et al[29]	Japan	Japanese, Korean, Chinese, Thai	rs9277542 T	21.03/561	12.07/646	0.50	1.28E-15	Healthy control
	Cheng et al[24]	Taiwan		rs9277535 (GA + AA)	57.0/100	42.0/100	1.83	0.034
	Hu et al[28]	China mainland	Chinese	DP rs9277535 (GG/AG/AA)	(31.5/49.9/18.6)/1344	(43.5/45.4/11.1)/1344	0.60	1.69E-10
				DQ rs7453920 (GG/AG/AA)	(79.2/19.6/1.2)/1344	(86.5/13.1/0.4)/1344	0.60	7.61E-7
				DQ rs2856718 (AA/AG/GG)	(25.8/49.4/24.8)/1344	(31.5/50.5/18.0)/1344	0.75	0.001
				DP rs3077 (GG/AG/AA)	(46.3/42.9/18.6)/1344	(51.5/40.5/8.0)/1344	0.81	0.0083
	Yan et al[25]	China mainland	Chinese	rs3077 AA	21.9/64	8.6/282	0.29	0.0017	Meta-analysis
	Yan et al[25]	China mainland	Chinese	rs9277535 AA	25.0/64	9.6/282	0.26	4E-4
	Cho et al[20]	South Korea	Koreans	DRB1*1302	14/80	19/384	4.34	2E-4	Sample bias
				DRB1*1502	12/80	32/384	2.21	0.0376
				DQB1*0302	20/80	49/384	2.12	0.0172
				DQB1*0609	8/80	6/384	7.24	0.0006
	Kummee et al[17]	Thailand	Thais	DRB1*13	8.0/100	4.7/150	0.04	0.0008
	Thomas et al[31]	United States	European-American/African-American	DPB1*04:01	59.1/421	48.6/241	0.56	0.003
			European-American/African-American	rs9277534 (AA + AG)	90.15/406	80.17/232	0.37	1E-4
			European-American	DPB1*04:01	70.3/320	58.4/185	0.55	0.01
			African-American	DPB1*04:01	22.4/85	8.7/46	0.27	0.05	Small sample size
	Fletcher et al[35]	India	Indian	DRB1*03:01	12.94/85	1.2/83	0.08	0.007	Small sample size
	Mbarek et al[34]	Japan	Japanese	rs2856718 (AA/AG/GG)	(23.16/48.3/28.54)/6486	(36.06/45.57/18.37)/2662	1.56	3.99E-37	GWAS-meta-analysis
				rs7453920 (A/G)	(2.91/28.08/69.01)/6496	(1.01/17.71/81.28)/2665	1.81	5.98E-28	HBsAg(-) diseases control
				DQA10102-DQB10604	6.59	1.22	0.16	3.42E-13
				DQA10101-DQB10501	4.77	1.68	0.39	1.06E-5
	Seto et al[51]	Hong Kong	Chinese	DP rs3077	25.4/203	19.2/203	0.699	0.035
	Seto et al[51]	Hong Kong	Chinese	haplotype block GAT (rs3077/rs9277378/rs3128917)	3.7/203	6.9/203	2.17	0.034
Cytokines
TNF	Kim et al[43]	South Korea	Koreans	TNF-α-863 (A/C)	23.3/279	30.5/1038	1.52-1.58	0.003-0.004
				TNF-α-863 (C/C)	74.8/279	65.9/1038
				TNF-α-863 (A/A)	1.9/279	3.6/1038
				TNF-α-308 (A/G)	11.3/283	6.5/1040	0.56-0.57	0.01
				TNF-α-308 (A/A)	0/283	0.1/1040
				TNF-α-308 (G/G)	88.7/283	93.4/1040
				TNF-α (-1031T; -863C; -857C; -308G; -238G; -163G)	32.6/276¹	31.3/1038¹	0.67-0.78	0.003-0.006
				TNF-α (-1031T; -863C; -857C; -308G; -238G; -163G)	36.2/276²	29.1/1038²	0.67-0.78	0.003-0.006
	Kummee et al[17]	Thailand	Thais	-863 C/C	70.0/100	56.6/150	0.46	0.01
	Zhang et al[46]	China mainland	Chinese	TNF-α-857 TT	83/2012	218/5267	0.701	0.032	Meta-analysis
	Shi et al[47]	China mainland	Asian	TNF-α-857 T	/2702	/4929	0.82	0.008	Meta-analysis
	Du et al[44]	China mainland	Chinese	857 TT	17.48/143	9.18/196	0.48	0.03
	Du et al[44]	China mainland	Chinese	Haplotype GGCCT	37.59/143	25.74/196	0.59	0.03
	Al-Qahtani et al[54]	Saudi Arabia	Saudi Arabian	rs12979860T	23.0/304	28.0/824	1.307	0.0183
				rs12980275 G	27.0/304	19.0/824	0.642	1E-4
				rs8105790 C	22/304	17/824	0.746	0.0133
IL-10	Cheong et al[42]	South Korea	Koreans	IL-10 -592 (CC)	12.7/204	7.5/412	0.40	0.003
IL-10	Zhang et al[46]	China mainland	Chinese	-592A			0.799	0.007	Meta-analysis
IL-28B	Seto et al[51]	Hong Kong	Chinese	Haplotype block CG (rs12979860/rs8099917)	0.2/203	2.5/203	10.50	0.026
Other genes
SPP1	Shin et al[62]	South Korea	Koreans	SPP1-ht2[T-T-C-T-A]	45.11/286	37.44/158	1.44	0.006
CCR5	Ahn et al[72]	South Korea	Koreans	59029G	29.6/243	19.8/349	1.71	0.006
CCR5	Ahn et al[72]	South Korea	Koreans	59353T	29.6/243	19.8/349	1.71	0.006
Persistence
HLA	Thio et al[12]	United States	Caucasians	B*08	8.1/342	12.2/194	1.59	0.03
				B*44	11.9/342	19.4/194	1.82	0.001
				Cw*0501	6.8/342	12.1/194	1.81	0.009
				Cw*1601	2.4/342	5.3/194	2.14	0.03
				DQB1*0201	20.1/342	27.8/194	1.56	0.004
				DRB1*0301	9.6/342	15.1/194	1.66	0.009
				A0101-B08-DQA10501-DQB10201-DRB1*0301	5.3/342	8.0/194	1.58	0.09
				B44-Cw1601	2.4/342	5.4/194	2.23	0.02
				B44-Cw0501	5.3/342	10.4/194	1.99	0.006
				B44-DRB10701	4.6/342	7.8/194	1.83	0.03
				B44-Cw1601-DRB1*0701	2.0/342	4.3/194	2.21	0.04
	Thio et al[32]	United States	African-Americans	DQA1*0501	20/60	40/31	2.6	0.05	Small sample size
				DRB1*0301	12/60	32/31	3.9	0.01
				DQA10501-DQB10301	11/60	27/31	3.0	0.005
				DQA10501-DQB10301-DRB1*1102	0.8/60	8.5/31	10.7	0.01
	Almarri et al[33]	Qatar	Qatarians	D7	16/31	57/21	3.73	0.05	Small sample size
	Wu et al[13]	Taiwan	Han Chinese	B35	1.9/324	4.6/98	2.63	0.034
				DR12	13.6/324	23/98	2.1	0.0022
				DR*1202	9.9/324	16.8/98	1.81	0.024
			Taiwanese Aborigines	A*0206	3.9/229	8.7/138	2.85	0.0029
	Albayrak et al[14]	Turkey	Turks	B35	0.2/30	46.7/75	0.286	< 0.005	Small sample size
				CW4	13.33/30	44.0/75	0.286	< 0.005
				DQ2	6.67/30	28.0/75	0.184	< 0.005
				DQ8	6.67/30	25.33/75	0.211	< 0.005
	Hu et al[15]	China mainland	Chinese	rs3130542			1.33	9.49E-14	GWAS-Meta-analysis
	Hu et al[15]	China mainland	Chinese	rs4821116			0.82	1.71E-12
	Kamatani et al[21]	Japan	Japanese	HLA-DPA10202-DPB10501	34.7/2100	42.8/1300	1.45	5.79E-6
	Kamatani et al[21]	Japan	Japanese	HLA-DPA10202-DPB10301	1.8/2100	3.6/1300	2.31	0.002
	Mbarek et al[34]	Japan	Japanese	DQA10102-DQB10303	0.25/614	1.91/748	19.03	8.39E-5
	Mbarek et al[34]	Japan	Japanese	DQA10301-DQB10601	0.42/614	2.45/748	5.02	7.34E-5
	Li et al[27]	China mainland	southern Chinese	HLA-DP rs2395309 G	257/524	1367/2107	1.31	9.63E-7
			southern Chinese	rs9277535 G	208/524	1195/2107	1.33	1.67E-7
			northern Chinese	HLA-DP rs2395309 G	121/304	302/600	1.2	0.021
			northern Chinese	rs9277535 G	75/304	206/600	1.26	8.37E-5
	Fletcher et al[35]	India	Indian	DRB1*07:01	24.71/85	57.83/83	3.76	< 0.005	Small sample size
	Fletcher et al[35]	India	Indian	HLA-B*44	3.45/85	18.07/83	6.23	0.007
	Ramezani et al[16]	Iran	Iranian	A*33	0/30	10.16/64		< 0.008	Small sample size
	O'Brien et al[30]	United States	European	rs3077				3.00E-7	Liver tissues
	O'Brien et al[30]	United States	European	rs9277535				0.001	Gene expression study
	Thomas et al[31]	United States	European-American/African-American	DPB1*01:01	14.3/421	21.2/241	1.86	0.01
	Thomas et al[31]	United States	African-American	DPB1*01:01	37.7/85	60.9/46	2.7	0.01	Small sample size
	Cho et al[20]	South Korea	Koreans	DRB1*0701	7/80	69/384	0.43	0.0458	Sample bias
	Cho et al[20]	South Korea	Koreans	DQB1*0301	17/80	126/384	0.55	0.047
	Guo et al[23]	China mainland	Chinese	rs9277535 G	553/571	498/521	0.56	5.61E-9
				rs2395309 G	564/571	496/521	0.71	2E-4
				rs3077 G	562/571	514/521	0.64	6.00E-6
				rs2301220 T	557/571	509/521	0.67	4.44E-5
				rs9277341 C	563/571	511/521	1.77	1.28E-5
				rs3135021 G	566/571	514/521	0.78	3.00E-3
				rs10484569 A	564/571	514/521	1.6	3.20E-6
				rs3128917 G	566/571	519/521	1.91	4.62E-11
				rs2281388 A	556/571	502/521	1.66	4.65E-7
				rs3117222 T	552/571	511/521	0.51	2.70E-11
				rs9380343 T	562/571	501/521	0.61	4.95E-7
	Corrêa Bde et al[36]	Brazil	Brazilian	DRB1*09	3.6/256	12.5/64	4.2	0.016	Male gender
	Corrêa Bde et al[36]	Brazil	Brazilian	DRB1*08	12.2/256	27.3/64	2.54	0.031	Aged 39 years or younger
Cytokines
TNF	Kim et al[43]	South Korea	Koreans	TNF-α (-1031C; -863A; -857C; -308G; -238G; -163G)	23.2/276¹	288.8/1038¹	1.42-1.46	0.01-0.02
	Kim et al[43]	South Korea	Koreans	TNF-α (-1031C; -863A; -857C; -308G; -238G; -163G)	1.8/276²	3.4/1038²	1.42-1.46	0.01-0.02
	Fletcher et al[35]	India	Indian	TNF-rs1800630 AA	4.1/150	11.9/137	2.28	< 0.01
	Fletcher et al[35]	India	Indian	TNF-rs1799964 CC	15.0/150	20.8/137	2.21	< 0.01
	Zheng et al[45]	China mainland	European	TNF-α-238 (GA + AA)	/3181	/5245	2.22/4.46	0.032/0.002	Meta-analysis
	Du et al[44]	China mainland	Chinese	-238GG	93.01/143	97.96/196	4.08	0.02
				-863CA	16.08/143	25.51/196	1.79	0.04
				haplotypes GGCAT	13.72/143	31.40/196	2.85	1E-4
				haplotypes GGTAT	3.46/143	6.93/196	4.15	4E-4
	Höhler et al[41]	Germany	German	-238 A	6.0/32	25.0/71		< 0.04
	Cheong et al[42]	South Korea	Korean	TNF-α -308 (GG/GA/AA)	(85.8/13.7/0.5)/204	(88.8/10.9/0.2)/412	0.58	0.039
	Cheong et al[42]	South Korea	Korean	TNF-α haplotype (-308/-238)	75.5/204	82.8/412	0.56	0.007
	Zhang et al[46]	China mainland mainland	Chinese	TNF-α-308A	/2012	/5267	0.585	0.002	Meta-analysis
IL28B	Kim et al[50]	South Korea	Koreans	rs12979860 CC	85.9/220²	93.5/154²		0.013
				rs12980275 AA	85.6/243²	91.1/203²		0.042
				rs8099917 TT	89.3/241²	94.1/204²		0.035
IL-18	Li et al[61]	China mainland	Chinese	rs1946518 AA	60/301	141/501	1.573	0.009
Other genes
SPP1	Shin et al[62]	South Korea	Koreans	SPP1-ht2–bearing genotype	37.44/428	45.11/331	1.44	0.006
GNLY	Park et al[63]	South Korea	Koreans	rs2886767 TT	2.76/107	10.78/206	2.44	0.015
				rs1561285 CC	1.25/107	2.77/206	3.78	0.008
				rs11127 CC	2.01/107	10.28/206	3.26	0.004
CCR5	Suneetha et al[73]	India	Indian	CCR5Delta32	0.73/408	4.2/214		0.005
MBL	Thomas et al[75]	United Kingdom	Caucasian	codon 52	4.0/98	27.0/33		4E-4
MBL	Thio et al[80]	United States	American	-221C	17.7/338	23.4/189	1.38	0.04

¹Heterozygosity;

²Homozygosity. HLA: Human leukocyte antigen; TNF: Tumor necrosis factor; IL: Interleukin; SPP1: Secreted phosphoprotein-1; CCR5: C-C chemokine receptor type 5; GNLY: Granulysin; MBL: Mannose-binding lectin; GWAS: Genome-wide association study.

Citation: Zeng Z. Human genes involved in hepatitis B virus infection. World J Gastroenterol 2014; 20(24): 7696-7706
URL: https://www.wjgnet.com/1007-9327/full/v20/i24/7696.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i24.7696