Hepatitis B virus mutations related to liver disease progression of Korean patients

Table 1 Mutations in 4 hepatitis B virus regions related to the progression of liver diseases in Korean chronic patients

Region		Mutations related to severe liver diseases	P value	Ref.
PreC/C	PreC	W28* [HCC 12/35 (34.3%) vs LC+ CH + C 5/35 (14.3%)]	0.093	Kim et al[11]
	C	P5H/L/T [HCC 5/35 (14.3%) vs LC + CH + C 0/35 (0%)]	0.020	Kim et al[11]
		E83D [HCC 4/35 (11.4%) vs LC + CH + C 0/35 (0%)]	0.039	Kim et al[11]
		I97F/L [HCC 13/35 (37.1%) vs LC + CH + C 4/35 (11.4%)]	0.024	Kim et al[11]
		L100I [HCC 6/35 (17.1%) vs LC + CH + C 1/35 (2.9%)]	0.046	Kim et al[11]
		Q182K/* [HCC 4/35 (11.4%) vs LC + CH + C 0/35 (0%)]	0.039	Kim et al[11]
PreS	preS1	W4P/R [HCC 13/96 (13.5%) vs CH 0/32 (13.2%)]	0.028	Lee et al[9]
		PreS1 start deletion [HCC 9/40 (22.5%) vs C 1/38 (2.6%)]	0.048	Mun et al[16]
	preS2	F141L [HCC 26/99 (26.3%) vs LC 2/52 (3.8%)]	0.001	Mun et al[15]
		PreS2 deletion [HCC 35/99 (35.4%) vs CH 6/45 (13.3%)]	0.020	Mun et al[15]
S	S	W182* [HCC + LC 56/176 (31.8%) vs CH + C 17/99 (17.2%)]	0.010	Lee et al[12]
X	X	V5M/L [HCC 30/60 (50.0%) vs LC 11/42 (26.2%)]	0.024	Kim et al[22]
		P38S [HCC 13/60 (21.7%) vs C 2/41 (4.9%)]	0.023	Kim et al[22]
		H94Y [HCC 24/60 (40.0%) vs C 2/41 (4.9%)]	< 0.001	Kim et al[22]
		I127T/N [HCC 22/60 (36.7%) vs CH 6/41 (14.6%)]	0.023	Kim et al[22]
		KV130MI [HCC 52/60 (86.7%) vs CH 25/41 (61.0%)]	0.004	Kim et al[22]

HCC: Hepatocellular carcinoma; LC: Liver cirrhosis; CH: Chronic hepatitis; C: Carrier.