Optimal treatment strategy for Helicobacter pylori: Era of antibiotic resistance

Table 1 Randomized-controlled trials for the first-line non-bismuth containing quadruple therapies

Author	Country	Publication year	Therapy regimen		Patients (n)	Eradication rate (ITT)
Wu et al[35]	Taiwan	2010	S	E 40 mg bd + AMX 1 g bd for 5 d followed by	115	92.3%
				E 40 mg bd + CLA 500 mg bd + MET 500 mg bd for 5 d
			C	E 40 mg bd + AMX 1 g bd + CLA 500 mg bd + MET 500 mg bd for 10 d	117	93.0%
Huang et al[38]	Taiwan	2012	S	L 30 mg bd + AMX 1 g bd for 5 d followed by	85	80.0%
				L 30 mg bd + CLA 500 mg bd +MET 500 mg bd for 5 d
			C	L 30 mg bd + AMX 1 g bd + CLA 500 mg bd + MET 500 mg bd for 10 d	84	88.1%
McNicholl et al[39]	Spain	2013	S	O 20 mg bd + AMX 1 g bd for first 5 d followed by	170	81%
				O 20 mg bd + CLA 500 mg bd + MET 500 mg bd for 5 d
			C	O 20 mg bd + AMX 1 g bd + CLA 500 mg bd + MET 500 mg bd for 10 d	168	87%
Lim et al[40]	Korea	2013	S	R 20 mg bd + AMX 1 g for 7 d followed by	86	75.6%
				R 20 mg bd + CLA 500 mg bd + MET 500 mg bd for 7 d
			C	R 20 mg bd + AMX 1 g bd + CLA 500 mg bd + MET 500 mg bd for 14 d	78	80.8%
Zullo et al[41]	Italy	2013	S	O 20 mg qd + AMX 1 g qd 5d followed by	90	91.1%
				O 20 mg qd + CLA 500 mg qd + TIN 500 mg qd for 5 d
			C	O 20 mg qd + AMX 1 g qd + CLA 500 mg qd + TIN 500 mg qd for 5 d	90	85.5%
			H	O 20 mg qd + AMX 1 g qd for 14 d plus	90	80.0%
				CLA 500 mg qd + TIN 500 mg qd for last 7 d
Sardarian et al[42]	Iran	2013	S	P 40 mg bd + AMX 1 g bd for 5 d followed by	210	76.7%
				P 40 mg bd + CLA 500 mg bd + TIN 500 mg bd for 5 d
			H	P 40 mg bd + AMX 1 g bd for 14 d plus	210	89.5%
				CLA 500 mg bd + TIN 500 mg bd for last 7 d
Molina-Infante et al[37]	Spain, Italy	2013	C	O 40 mg bd + AMX 1 g bd + CLA 500 mg bd + NIT 500 mg bd for 14 d	172	91.7%
			H	O 40 mg bd + AMX 1 g bd for 14 d plus	171	90.0%
				CLA 500 mg bd + TIN 500 mg bd for last 7 d

ITT: Intention-to-treat; S: Sequential therapy; C: Concomitant therapy; H: Hybrid therapy; AMX: Amoxicillin; CLA: Clarithromycin; MET: Metronidazole; TIN: Tinidazole; E: Esomeprazole; L: Lansoprazole; P: Pantoprazole; O: Omeprazole; R: Rabeprazole; bd: Two times a day; qd: Once a day.