Topic Highlight
Copyright ©2014 Baishideng Publishing Group Co.
World J Gastroenterol. May 14, 2014; 20(18): 5435-5441
Published online May 14, 2014. doi: 10.3748/wjg.v20.i18.5435
Table 1 Possible risk markers for liver injury
ORFMajor MutationsClinical statusRef.
PreS1/S2/S
preS deletionCHB[49-51]
FHB[52,53]
AHB[54,55]
HCC[56-61,78]
Occult infection[62]
W4P/Rmale predominace HCC and LC[23]
S
T207ALC[63]
T770CHCCGenBank no.AY206393
C695Occult infection[64]
T207AHBsAg(-)[65-67]
X
A1762T/G1764ALC,HCC[68,69,71,75-79]
mild liver histology[72]
C1653TLC,HCC[75,77-79]
T1753VLC,HCC[75,77-80]
G1386MLC,HCC
B1499LC,HCC[75]
G1613ALC,HCC[77,79]
A1727GLC,HCC[76,77]
G1757ALC,HCC[76,77]
C1766TLC,HCC[76-78]
T1768ALC,HCC[77,78]
A1727GHCC[76]
C1773THCC[76]
preC/C
A1896TFHB,HCC[37,80]
G1899AHCC[37]
C1913A or C1914THCC[37]
A2149C/THCC[37]
A2188T/CHCC[37]
C2198AHCC[37]
C2444A/THCC[37]
core antigen internal deletionsCHB[82,83]
HCC[84]
immune-suppressed patients[85]
P
G741HHCC[89,93]
CHB[90-93]