Acute hepatitis B of genotype H resulting in persistent infection

Table 1 Laboratory findings at first visit to our hospital

Hematology		Blood chemistry		Viral markers		Immunology		Coagulation
WBC	7400/μL	TP	7.4 g/dL	Anti-HA IgM	(-)	IgA	183 mg/dL	PT%	95%
Neutrophil	72.0%	Albumin	4.5 g/dL	Anti-HCV	(-)	IgG	1168 mg/dL	APTT	36.4 s
Eosinophil	1.0%	T-Bil	11.1 mg/dL	HBsAg	(+) 197333	IgM	220 mg/dL
Basophil	0.0%	D-Bil	8.0 mg/dL	Anti-HBc IgM	(+) 25.5 C.O.I	ANA	× 40, homogeneous
Monocyte	10.0%	AST	1942 IU/L	HBeAg	(+) 253 C.O.I
Lymphocyte	17.0%	ALT	2963 IU/L	Anti-HBe	(-) 0.0 %
RBC	457/μL	ALP	612 IU/L	HBV-DNA	7.7 log copies/mL
Hemoglobin	16.0 g/dL	γGTP	756 IU/L	Anti-HIV	(-)
Hematocrit	46.4%	LDH	739 IU/L	RPR	(-)
Platelet	36.6 × 104/μL	BUN	8.2 mg/dL	TPHA	(+)
		Creatinine	0.64 mg/dL	Anti-CMV IgG	(+)
		T-Chol	225 mg/dL	Anti-CMV IgM	(-)
				Anti-EBV EBNA	(+)
				Anti-EBV EA IgG	(-)
				Anti-EBV VCA IgG	(+)
				Anti-EBV VCA IgM	(-)

WBC: White blood cells; RBC: Red blood cells; ANA: Antinuclear antibody; TP: Total protein; T-Bil: Total bilirubin; D-Bil: Direct bilirubin; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; γGTP: γ-glutamyltranspeptidase; LDH: Lactase dehydrogenase; BUN: Blood urea nitrogen; T-Chol: Total cholesterol; PT: Prothrombin activity; APTT: Activated partial thromboplastin time; C.O.I: Cutoff index; HA: Hepatitis A; HCV: Hepatitis C virus; HBsAg: Hepatitis B surface antigen; HBc: Hepatitis B core; HBeAg: Hepatitis B e-antigen; HBV: Hepatitis B virus; HIV: Human immunodeficiency virus; RPR: Rapid plasma regain; TPHA: Treponema pallidum hemagglutination assay; CMV: Cytomegalovirus; EBV: Epstein-Barr virus; EBNA: Epstein-Barr virus nuclear antigen; EA: Early antigen; VCA: Viral capsid antigen.

Table 2 Genotype H strains reported in Japan

No.	Patient		Hypothesized source of infection		HIV infection1	Clinical feature	Accession number (Ref.)
	Age	Gender	Route	Place
1	52	Male	Unknown	Japan	NA	Unknown blood donor	AB179747, [18]
2	61	Male	Sexual contact (heterosexual)	Thailand	NA	Chronic	AB205010, [19]
3	46	Male	Sexual contact (bisexual)	South America	(+)	Chronic	AP007261, [20]
4	38	Male	Sexual contact (homosexual)	Unknown	NA	Chronic	AB298362, [21]
5	65	Male	Unknown	Japan	NA	Acute	EF157291, [22]
6	35	Male	Unknown	Japan	NA	Acute	AB266536, [23]
7	60	Male	Sexual contact (homosexual)	Japan	(-)	Acute	AB275308, [24]
8	60	Male	Sexual contact (heterosexual)	Unknown	(+)	Chronic	AB353764, [25]
9	47	Male	Unknown	Japan	(-)	Acute to chronic	AB846650, this paper

¹NA: Not available; HIV: Human immunodeficiency virus.