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Copyright ©2014 Baishideng Publishing Group Co.
World J Gastroenterol. Mar 21, 2014; 20(11): 2913-2926
Published online Mar 21, 2014. doi: 10.3748/wjg.v20.i11.2913
Table 1 Target sequences of short interfering RNA of a selected group of DEAD-box proteins used in this study
siRNASequenceRef.
ControlAAA ACG UUC UGA UGC CUU AAGFrom SARS genome
DDX3CGC UUG GAA CAG GAA CUC UUUChang et al[100]
DDX5AAG UGG AAU CUU GAU GAG CUGGoh et al[68]
DDX6GCA GAA ACC CUA UGA GAU UUUChu and Rana[89]
Table 2 Summary of selected members of the DEAD-box family that are involved in hepatitis C virus replication and/or have been implicated in the development of hepatocellular carcinoma
Dead-box familyAlternate namesInteraction with HCVEffect on HCV replicationRef.Effect on HCCRef.
DDX1DBP-RB UKVH5dHCV 3’ (+) UTR and 5’ (-) UTRUnknownNAUnknownNA
DDX3DDX3X DBX DDX14 HLP2HCV coreRequired for HCV replicationAriumi et al[59] Randall et al[60] Angus et al[66]Overexpressed in HCCHuang et al[97] Li et al[98] Liu et al[99]
Downregulated in HCCChang et al[100] Chao et al[101]
DDX5p68 G17P1 HLR1 HUMP68HCV NS5BInhibit an early step and promote a late step in viral replicationData presented herein Kuroki et al[75]Downregulated in HCCKitagawa et al[86]
DDX6Rck P54 HLR2HCV coreRequired for HCV replicationScheller et al[78] Jangra et al[79] Pager et al[80] Huys et al[81]Overexpressed in HCCMiyaji et al[88]
DDX17P72 RP3-434P1.1 RH70UnknownUnknownNADownregulated in HCCKitagawa et al[86]
DDX20Gemin3 DP103UnknownUnknownNADownregulated in HCCTakata et al[94]