Sodium alginate ameliorates indomethacin-induced gastrointestinal mucosal injury via inhibiting translocation in rats

Table 1 Effects of drugs on loss of body weight, food intake and feces weight

	Change body weight (g)	Change food intake (g/rat)	Change feces weight (g/rat)
Control	7.5 ± 2.2	19.7 ± 1.4	6.3 ± 0.7
Indomethacin	-5.2 ± 5.8b	8.5 ± 2.6b	3.5 ± 0.6b
AL-Na (250 mg/kg)	1.8 ± 7.6	15.1 ± 4.2a	4.7 ± 1.2
AL-Na (500 mg/kg)	7.5 ± 2.8d	19.2 ± 2.3d	5.8 ± 0.8d
Reb (100 mg/kg)	-1.2 ± 4.9	15 ± 3.1	5 ± 0.7

Differences of weigh change 24 h after indomethacin were measured. Data are presented as the means ± SE (n = 8). Significantly different from the control group at

^bP < 0.01 (Student’s t-test). Significantly different from the indomethacin group at

^aP < 0.05 and

^dP < 0.01 (Dunnett’s test). AL-Na: Sodium alginate; Reb: Rebamipid.

Table 2 Effects of sodium alginate on number of enterobacteria in ileal mucosa

	n	Total number of enterobacteria log CFU/g tissue
Control	6	6.84 ± 0.44
Indomethacin	6	7.82 ± 0.42b
AL-Na (250 mg/kg)	6	7.26 ± 0.53
AL-Na (500 mg/kg)	6	6.96 ± 0.83a

Number of enterobacteria 24 h after indomethacin administration was counted. Data are presented as the means ± SE. Significantly different from the control group at

^bP < 0.01 (Student’s t-test). Significantly different from the indomethacin group at

^aP < 0.05 (Dunnett’s test). AL-Na: Sodium alginate.