Brief Article
Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Feb 7, 2013; 19(5): 721-726
Published online Feb 7, 2013. doi: 10.3748/wjg.v19.i5.721
Table 1 Baseline demographics (n = 163) n (%)
Age (yr)
Mean age52.0 (24-86)
Mean age at start47.4 (20-81)
Gender
Males113 (69.3)
Females50 (30.7)
Pre-treatment Biopsies134 (82.2)
Duration of therapy (mo)
Range3-46
Mean25.63
Median23
Patients > 24 mo79 (48.5)
Patients > 36 mo49 (30.1)
Co-infection
Hepatitis C1 (0.61)
HBV DNA load (IU/mL)
> 100  00095 (58.3)
2000-100  00045 (27.6)
12-200023 (14.1)
HBe antigen status41 (25.2)
e antigen positive112 (68.7)
e antigen negative10 (6.1)
Unknown
ALT (U/L)
10-4039 (23.9)
40-400118 (72.4)
> 4005 (3.01)
Unknown1 (0.61)
Fibrosis score0-10 (6.13)
135 (82.82%)1-61 (37. 4)
2-38 (23.3)
3-17 (10.4)
4-9 (5.52)
Unknown-27 (16.6)
Table 2 Follow up of DNA values and cumulative rates of complete and partial virological suppression n (%)
Month06121824303642
Patients with DNA163 (100)158 (96.9)141 (86.5)121 (74.2)105 (64.4)76 (46.6)56 (34.4)24 (14.7)
Complete virological suppression0/169 (0)104/158 (65.8)117/141 (83.0 )96/121 (74.4)94/105 (89.5)65/76 (85.5)46/56 (82.1)19/24 (79.2)
Cumulative CVS0%66.7%88.8%85.1%94.8%93.2%92.2%91.6%
Partial virological suppression22/163 (13.5)141/158 (89.2)133/141 (94.3)117/121 (90.7)100/105 (95.2)75/76 (98.7)54/56 (96.4)23/24 (95.8)
Cumulative PVS13.5%89.2%94.9%92.1%96.3%99.0%97.3%96.6%
Table 3 Complete virological suppression based on age and HBeAg status
Age-log rank 0.001 (median)
< 40 yr-40-55 yr-> 55 yr-
12 mo (9.25-14.75)6 mo (5.01-6.99)6 mo (5.24-6.76)
Hepatitis B e antigen negative status-log rank 0.19 (median)
< 40 yr-40-55 yr-> 55 yr-
6 mo (4.05-7.95)6 mo (4.99-7.02)6 mo (5.59-6.41)
Hepatitis B e antigen positive status-log rank 0.19 (median)
< 40 yr-40-55 yr-> 55 yr-
18 mo (7.37-28.63)18 mo (14.17-26.47)6 mo (6.5-17.5)
Hepatitis B e antigen seroconversion rate based on age-log rank 0.559 (median)
< 40 yr-40-55 yr-> 55 yr-
36 mo (20.55-51.45)30 mo (18.46-41.54)6 mo (9.8-32.2)