Clinical features and prognosis in colorectal cancer patients with different ethnicities in Northwest China

Table 1 Characteristics of colorectal cancer patients of different ethnicities n (%)

Characteristic	Han (n = 1210)	Uyghur (n = 211)	P value
Age (yr)			0.000
< 30	9 (0.7)	21 (10.0)
30-50	230 (19.0)	71 (33.6)
50-70	580 (47.9)	94 (44.5)
≥ 70	391 (32.3)	25 (11.8)
Gender			0.040
Male	694 (57.4)	105 (49.8)
Female	516 (42.6)	106 (50.2)
Occupation			0.000
Cadre (Office worker)	511 (42.2)	61 (28.9)
Physical worker	337 (27.9)	30 (14.2)
Farmer and herder	205 (16.9)	90 (42.7)
Unemployed	157 (13.0)	30 (14.2)
Blood type			0.013
A	378 (31.2)	44 (20.9)
B	386 (31.9)	81 (38.4)
AB	139 (11.5)	32 (15.2)
O	307 (25.4)	54 (25.6)
Tumor location			0.054
Rectum	704 (58.2)	141 (66.8)
Left hemi colon	300 (24.8)	39 (18.5)
Right hemi colon	206 (17.0)	31 (14.7)
Tumor size			0.183
< 4	196 (16.2)	24 (11.4)
4-8	838 (69.3)	157 (74.4)
> 8	176 (14.5)	30 (14.2)
Tumor differentiation			0.360
Poorly	203 (21.1)	42 (24.6)
Moderate	606 (63.0)	108 (63.1)
Well	153 (15.9)	21 (13.3)
Histopathology			0.012
Adenocarcinoma	1031 (85.2)	175 (82.9)
Mucinous cell	146 (12.1)	22 (10.4)
Signet-ring cell	33 (2.7)	14 (6.6)
Gross type			0.395
Invasive	153 (12.6)	20 (9.5)
Ulcerous	576 (47.6)	101 (47.9)
Fungus	481 (39.8)	90 (42.7)
T			0.673
1	34 (2.8)	4 (1.9)
2	249 (20.6)	40 (19.0)
3	520 (43.0)	99 (46.9)
4	407 (33.6)	68 (32.2)
N			0.071
No	494 (40.8)	77 (36.5)
≤ 4	538 (44.5)	111 (52.6)
> 4	178 (14.7)	23 (10.9)
M			0.692
No	1039 (85.9)	179 (84.8)
Yes	171 (14.1)	32 (15.2)
Staging			0.669
I	129 (10.7)	20 (9.5)
II	362 (29.9)	56 (26.5)
III	548 (45.3)	103 (48.8)
IV	171 (14.1)	32 (15.2)
CEA			0.992
≤ 3.4	301 (27.8)	52 (27.8)
> 3.4	780 (72.2)	135 (72.2)

T: Tumor infiltration depth; N: Number of lymph node; M: Metastasis at diagnosis; CEA: Carcinoembryonic antigen.

Table 2 Treatment, recurrence and survival n (%)

	Han (n = 1210)	Uyghur (n = 211)	P value
Chemotherapy			0.493
Yes	692 (57.2)	126 (59.7)
No	518 (42.8)	85 (40.3)
Radiotherapy			0.216
Yes	247 (20.4)	51 (24.2)
No	963 (79.6)	160 (75.8)
Surgery			0.872
Radical	1091 (90.2)	191 (90.5)
Palliative	119 (9.8)	20 (9.5)
Local recurrence			0.282
Yes	151 (12.5)	32 (15.2)
No	1059 (87.5)	179 (84.8)
Postoperative metastasis			0.535
Yes	620 (51.2)	113 (53.6)
No	753 (48.8)	98 (46.4)
Metastatic site			0.224
No	591 (48.8)	97 (46.0)
Liver	394 (32.6)	81 (38.4)
Non-liver	225 (18.6)	33 (15.6)
Median overall survival	45	42	0.000
Median dis-free survival	62	49	0.005
Median tumor-specific survival	65	61	0.007

Table 3 Significant predictive factors for cancer-specific survival in a Cox proportional-hazard analysis

Prognostic factor	Univariate HR (95%CI)	P value	Multivariate HR (95%CI)	P value
Age	0.768 (0.706-0.836)	0.000	0.828 (0.751-0.913)	0.000
Ethnicity	1.494 (1.277-1.749)	0.000	1.316 (1.107-1.565)	0.002
Tumor site	0.918 (0.852-0.988)	0.023	0.972 (0.889-1.063)	0.531
Histopathological type	0.584 (0.537-0.634)	0.000	0.479 (0.307-0.748)	0.001
Tumor differentiation	1.201 (0.976-1.479)	0.028	1.421 (1.126-1.795)	0.003
T	1.475 (1.374-1.582)	0.000	1.378 (1.268-1.498)	0.000
N	1.684 (1.561-1.817)	0.000	1.169 (1.007-1.357)	0.040
M	3.829 (3.264-4.492)	0.000	1.179 (0.895-1.554)	0.243
Staging	2.009 (1.865-2.164)	0.000	1.579 (1.418-1.798)	0.000
Postoperative metastasis	2.538 (2.260-2.850)	0.000	2.329 (1.805-3.004)	0.000
Metastatic site	1.513 (1.416-1.617)	0.000	0.837 (0.716-0.978)	0.025

T: Tumor infiltration depth; N: Number of lymph node; M: Metastasis at diagnosis.