Photodynamic therapy vs radiofrequency ablation for Barrett’s dysplasia: Efficacy, safety and cost-comparison

Table 1 Characteristics factors of the patients n (%)

Variable	PDT (n = 33)	RFA (n = 53)
Age (yr)
Mean ± SD	70.7 ± 12.2	65.4 ± 12.7
Range	49-80	54-80
Sex
Female	3 (9)	14 (26)
Male	30 (91)	39 (74)
Body-mass index
Mean ± SE	27.8 ± 0.7	31.7 ± 1.3
Range	21-38	23-47
Length of Barrett's esophagus (cm)
Mean ± SD	5.4 ± 3.2	5.7 ± 3.2
Range	1.0-8.0	1.0-9.0

PDT: Photodynamic therapy; RFA: Radiofrequency ablation.

Table 2 Outcomes measures n (%)

	PDT	RFA
Primary outcomes
Complete Response IM
ITT	13/33 (39.4)	27/53 (50.9)
PP	13/32 (40.6)	35/61 (57.4)
Complete Response Dysplasia
ITT	18/33 (54.5)	47/53 (88.7)
PP	18/32 (56.3)	56/61 (91.8)
Secondary outcomes
Complications
Perforation	1/32 (3.1)	0/50 (0.00)
Stricture	9/32 (28.1)	2/50 (4.0)
Cost per session	$9449	$1888 (HALO-360)
		$1486 (HALO-90)

PDT: Photodynamic therapy; RFA: Radiofrequency ablation; ITT: Intention-to-treat; PP: Per-protocol; IM: Intestinal metaplasia.