PNPLA3 I148M polymorphism and progressive liver disease

Table 1 Studies evaluating the association between the 148 Isoleucine to Methionine protein variant of patatin-like phospholipase domain-containing 3 polymorphism and liver fibrosis in patients affected by chronic hepatitis C virus infection, a leading cause of liver related mortality in Western countries

Study	Design	Patients	Outcome	OR	95%CI
Valenti et al[75]	Cross-sectional	819	Cirrhosis	1.5	1.2-1.9
Müller et al[76]	Cross-sectional	605	Cirrhosis	2.8	1.2-6.2
Trépo et al[77]	Cross sectionalprospective	537	Fibrosis stage	3.1	1.5-6.5
			Fibrosis progression	2.6	1.2-5.7