Brief Article
Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Sep 7, 2013; 19(33): 5493-5499
Published online Sep 7, 2013. doi: 10.3748/wjg.v19.i33.5493
Table 1 Characteristics of the two polyethylene glycol bowel preparations
PEG-CS4-L PEG
Active ingredientsBisacodyl, PEG, citrates, simethiconePEG, sodium sulphate
Product description4 sachets; each containing PEG 4000 60.7 g, sodium citrate 1.066 g, citric acid 1.25 g, simethicone 80 mg8 sachets; each containing PEG 4000 29.5 g and sodium sulphate 2.843 g
Total volume2-L4-L
ElectrolytesSodium chloride, potassium chlorideSodium bicarbonate, sodium chloride, potassium chloride
Osmolality (mOsmol/kg)293288
Mixed withWaterWater
Diet prior to colonoscopyClear liquid after starting solution intakeClear liquid after starting solution intake
Timing of intake1-L of solution at 19:00 the day prior to procedure 1-L of solution at 7:00 the day of the exam3-L of solution at 17:00 the day prior to procedure 1-L of solution at 7:00 the day of the exam
Additional agents15 mg bisacodyl (3 tablets) at 16.00 the day prior to procedure
Table 2 Primary efficacy and other endpoints n (%)
OutcomeBIS + 2-L PEG-CS (n = 138)4-L PEG (n = 126)P value
Bowel cleansing
A (all segments as excellent or good)107 (77.5)105 (83.3)NS
B (at least one segment as fair)21 (15.2)11 (8.7)
C (at least one segment as poor)7 (5.1)8 (6.3)
D (exam not completed)3 (2.2)2 (1.6)
Successful (A + B)128 (92.8)116 (92.1)NS
Unsuccessful (C + D)10 (7.2)10 (7.9)
Tolerability
Nausea27 (19.6)26 (20.6) 0.575
Bloating11 (8.0)33 (26.2)< 0.001
Abdominal discomfort13 (9.4)5 (4.0) 0.079
Overall (any of previous ones)45 (32.6)57 (45.2) 0.035
Acceptance
Good70 (50.7)30 (23.8)< 0.001
Satisfactory55 (39.9)67 (53.2)
Not acceptable13 (9.4)22 (23.0)
Compliance
100% of solution drunk134 (97.1)110 (87.3) 0.010
75% of solution drunk4 (2.9)15 (11.9)
50% or less of solution drunk0 (0.0)1 (0.8)
Table 3 Quality of cleansing for each colonic segment
Caecum/ascending colon
Transverse colon
Descending colon
Sigmoid colon
Rectum
BIS + 2-L PEG-CS (n = 138)4-L PEG(n = 126)BIS + 2-L PEG-CS (n = 138)4-L PEG(n = 126)BIS + 2-L PEG-CS (n = 138)4-L PEG(n = 126)BIS + 2-L PEG-CS (n = 138)4-L PEG(n = 126)BIS + 2-L PEG-CS (n = 138)4-L PEG(n = 126)
Score
Excellent37.00%52.40%52.20%57.90%51.40%59.50%45.70%60.30%40.60%51.60%
Good50.70%37.30%38.40%34.90%37.00%31.00%39.90%28.60%43.50%39.70%
Fair7.20%4.00%5.10%2.40%6.50%5.60%9.40%5.60%12.30%4.00%
Poor2.90%4.80%2.20%3.20%5.10%3.20%5.10%4.80%3.60%4.00%
Missing2.20%1.60%2.20%1.60%0.00%0.80%0.00%0.80%0.00%0.80%