Meta-Analysis
Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Jul 28, 2013; 19(28): 4607-4615
Published online Jul 28, 2013. doi: 10.3748/wjg.v19.i28.4607
Table 1 Characteristics of included prospective studies for urinary trypsinogen activation peptide as a predictor of severity of acute pancreatitis
Ref.YearCountrySampling time after admissionCut-off value (nmol/L)Total (n)Male/female (n)Mild/severe (n)Mean age: male/female (yr)Etiology
Neoptolemos et al[32]2000MulticenterOn admission3517287/85137/3552 (29-84)Biliary 74, alcoholic 62, other 36
Liu et al[34]2002ChinaOn admission3541NA29/12NANA
Khan et al[33]2002United StatesOn admission355833/2539/1969 ± 19Biliary 26, alcoholic 18, HTC 3, postoperative (including ERCP) 9, idiopathic 2
Lempinen et al[35]2003FinlandOn admission35127NA98/29NABiliary 24, alcoholic 74, other 29
Johnson et al[37]2004MulticenterOn admission35190104/86164/2654 (42-70)Biliary 70, alcohol 65, other 55
Huang et al[38]2010ChinaOn admission35187112/75149/3860.4 ± 6.7;Biliary 139, alcoholic 19, other 29
59.5 ± 8.1
Table 2 Diagnostic parameters of included studies
Ref.Patients (n)Patients analyzed (mild/severe)TPFPFNTN
Neoptolemos et al[32]172132 (105/27)2230575
Liu et al[34]4141 (29/12)113126
Khan et al[33]5858 (39/19)199030
Lempinen et al[35]127118 (90/28)18161074
Johnson et al[37]190190 (164/26)123314131
Huang et al[38]187187 (149/38)24511498
Table 3 Meta-analysis outcomes of included studies
Trials (n)Patients (n)AUCDOR (95%CI)QP valueI2
All studies67260.838.67 (3.70-20.33)15.880.007268.50%
Study subgroups
Sample size ≥ 5056850.806.48 (3.05-13.74)10.280.036061.10%
Single center44130.8614.25 (3.39-59.80)12.920.004876.80%
1992 Atlanta Classification55360.8411.97 (4.17-34.36)13.650.008570.70%