Helicobacter pylori and Crohn’s disease: A retrospective single-center study from China

Table 1 Demographic, anthropometric and serologic data of enrolled patients

Group	CD (n = 229)	Control (n = 248)	P value
Age (yr)	46.2 ± 10.2	46.8 ± 9.4	0.79
Sex (male/female)	133/96	141/107	0.07
Smoking history	34.90%	18.10%	< 0.01
Alcohol intake	17.40%	8.10%	< 0.01
BMI (kg/m2)	24.5 ± 2.0	26.0 ± 2.2	< 0.01
Hypertension	14.80%	16.10%	0.09
Diabetes,	7.90%	6.90%	0.13
CRP (mg/L)	36.3 ± 20.8	5.5 ± 2.3	< 0.01
WBC (× 109/L)	9.7 ± 2.9	4.3 ± 0.9	< 0.01

BMI: Body mass index; CRP: C-reactive protein; WBC: White blood cell.

Table 2 Helicobacter pylori infection rate between different Crohn’s disease types n (%)

Group	H. pylori-positive	H. pylori-negative	P value
CD	62 (27.1)	167 (72.9)	< 0.01
Colonic CD	14 (31.1)	31 (68.9)	< 0.01
Small intestine CD	11 (28.9)	27 (71.1)	< 0.01
Ileocolonic CD	30 (26.8)	82 (73.2)	< 0.01
Extensive CD	7 (25.9)	27 (74.1)	< 0.01
Control	119 (47.9)	129 (52.1)

H. pylori: Helicobacter pylori; CD: Crohn’s disease.

Table 3 Helicobacter pylori infection between different severity of Crohn’s disease and control n (%)

Group	H. pylori-positive	H. pylori-negative	P value
CD	11 (34.3)	21 (65.7)	< 0.011
Colonic CD	27 (30.7)	61 (69.3)	< 0.011
Small intestine CD	24 (22.0)	85 (88.0)	< 0.011
Control	119	129

¹vs control group. H. pylori: Helicobacter pylori; CD: Crohn’s disease.