E2F transcription factors and digestive system malignancies: How much do we know?

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Jun 7, 2013 (publication date) through Apr 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 7, 2013; 19(21): 3189-3198
Published online Jun 7, 2013. doi: 10.3748/wjg.v19.i21.3189

Table 1 Possible role, correlations and prognostic significance of increased E2F1 expression in digestive system malignancies

Tumor	Role	Clinicopathological relationships	Prognostic significance	Ref.
Esophageal
Squamous cell carcinoma	Tumor-promoting	↑ tumor stage, ↑ histological grade, ↓ overall survival	Yes	[74,75]
Adenocarcinoma	Tumor-suppressing	↑ survival	Yes	[78]
Gastric adenocarcinoma	Tumor-suppressing	Localized disease, intestinal histological type, ↑ overall survival	Yes	[88]
Colorectal adenocarcinoma	Tumor-suppressing	↑ survival	Yes	[25,96]
Hepatocellular carcinoma	Tumor-suppressing		No	[108]
Pancreatic ductal adenocarcinoma	Tumor-promoting	↑ histological grade, ↓ disease-free survival	Yes	[119]

↑: Increased; ↓: Decreased.

Citation: Xanthoulis A, Tiniakos DG. E2F transcription factors and digestive system malignancies: How much do we know? World J Gastroenterol 2013; 19(21): 3189-3198
URL: https://www.wjgnet.com/1007-9327/full/v19/i21/3189.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i21.3189