Brief Article
Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Apr 28, 2013; 19(16): 2543-2549
Published online Apr 28, 2013. doi: 10.3748/wjg.v19.i16.2543
Table 1 Baseline characteristics of the patients n (%)
CharacteristicsTotal (n = 412)Severe hepatitis (n = 92)Non-severe hepatitis (n = 320)P valueProlonged cholestasis(n = 21)Non-prolonged cholestasis (n = 391)P value
Age1 (yr)34.4 ± 11.436.5 ± 11.533.8 ± 11.40.03542.6 ± 15.034.0 ± 11.10.013
Gender, male237 (57.5)62 (67.4)175 (54.7)0.03211 (52.4)226 (57.8)0.655
Etiology
Hepatitis A319 (77.4)67 (72.8)252 (78.8)8 (38.1)311 (79.5)
Toxic44 (10.7)17 (18.5)27 (8.4)10 (47.6)34 (8.7)
Unknown25 (6.1)1 (1.1)24 (7.5)0 (0)25 (6.4)
Hepatitis B16 (3.9)4 (4.3)12 (3.8)2 (9.5)14 (3.6)
Alcohol4 (1.0)1 (1.1)3 (0.9)0 (0)4 (1.0)
Hepatitis C2 (0.5)1 (1.1)1 (0.3)1 (4.8)1 (0.3)
Autoimmune2 (0.5)1 (1.1)1 (0.3)0 (0)2 (0.5)
Etiology, toxic44 (10.7)17 (18.5)27 (8.4)0.00110 (47.6)34 (8.7)< 0.001
ALT1 (IU/L)2053 ± 17592145 ± 22072027 ± 16110.392998 ± 10902110 ± 17720.001
ALP1 (IU/mL)155 ± 75152 ± 72156 ± 760.983153 ± 110156 ± 730.265
Bilirubin1 (mg/dL)5.6 ± 4.911.2 ± 6.73.9 ± 2.6< 0.00118.6 ± 6.94.9 ± 3.7< 0.001
Albumin1 (g/dL)3.9 ± 0.43.8 ± 0.44.0 ± 0.4< 0.0013.8 ± 0.43.9 ± 0.40.174
PT1 (%)81.0 ± 18.075.2 ± 22.783.7 ± 16.60.00384.6 ± 15.081.7 ± 18.60.721
GWT1, mm5.2 ± 5.57.2 ± 6.05.5 ± 5.30.0099.6 ± 6.75.7 ± 5.40.003
> 3233 (56.5)70 (70.7)168 (51.7)0.00417 (81.0)216 (55.2)0.025
> 7142 (34.5)36 (39.1)106 (33.1)0.04011 (52.4)131 (33.5)0.005
Arterial heterogeneity (+)294 (80.1)68 (73.9)226 (70.6)0.75515 (71.5)279 (71.3)1.000
Periportal tracking (+)348 (84.7)78 (84.8)270 (84.4)0.86918 (85.7)330 (84.4)1.000
LN number14.8 ± 3.05.1 ± 3.34.8 ± 2.90.5815.3 ± 3.74.8 ± 3.00.701
LN size1 (cm)0.97 ± 0.260.99 ± 0.280.96 ± 0.260.4650.97 ± 0.300.97 ± 0.260.743
≥ 0.8346 (84.5)79 (85.9)267 (83.4)0.63217 (81.0)329 (84.1)0.759
> 1162 (39.3)42 (45.7)120 (37.5)0.18310 (47.6)152 (38.9)0.494
Ascites (+)56 (13.6)17 (18.5)39 (12.2)0.1237 (33.3)49 (12.5)0.015
Spleen size1 (cm)10.9 ± 1.611.04 ± 1.6810.84 ± 1.600.41910.44 ± 1.710.91 ± 1.60.094
≥ 1295 (23.1)24 (26.1)71 (22.2)0.4833 (14.3)92 (23.5)0.431
Table 2 Relationship between computed tomography findings and liver chemistry (mean ± SD)
GWTLN maximum sizeLN numberSpleen sizeArterial heterogeneity
Periportal tracking
Ascites
Absence (n = 73)Presence (n = 294)P valueAbsence (n = 63)Presence (n = 348)P valueAbsence (n = 356)Presence (n = 56)P value
ALT(IU/L)0.234 (< 0.001)0.164 (0.001)-0.013 (0.798)0.119 (0.015)1504 ± 14782216 ± 1794< 0.0011994 ± 21392064 ± 16880.0741981 ± 17692509 ± 16410.005
ALP (IU/mL)0.180 (< 0.001)0.135 (0.006)0.150 (0.003)0.086 (0.082)145 ± 76159 ± 750.108133 ± 63159 ± 760.007154 ± 76164 ± 660.152
Bilirubin (mg/dL)0.319 (< 0.001)0.138 (0.005)0.202   (< 0.001)0.190 (< 0.001)5.6 ± 5.25.6 ± 4.90.4514.3 ± 5.15.8 ± 4.9< 0.0015.3 ± 4.77.0 ± 5.90.012
PT (s)-0.118 (0.017)-0.038 (0.445)0.072   (0.149)-0.092 (0.061)86 ± 1681 ± 180.03281 ± 2082 ± 180.79582 ± 1876 ± 170.006
Albumin (g/dL)-0.282 (< 0.001)-0.018 (0.717)-0.017 (0.739)-0.062 (0.206)4.0 ± 0.43.9 ± 0.40.4044.1 ± 0.43.9 ± 0.40.0024.0 ± 0.43.7 ± 0.4< 0.001
Table 3 Multivariate logistic regression analysis for the factors associated with severe acute hepatitis and prolonged cholestasis in acute hepatitis
VariablesOR95%CI for OR
P value
LowerUpper
Severe acute hepatitis
Age (yr)1.0070.9281.0330.579
Gender, male2.5691.4774.4690.001
Etiology, toxic3.5311.4448.6350.006
Albumin (g/dL)2.1541.2793.6290.004
GWT (mm)1.0611.0151.1100.009
Prolonged cholestasis in acute hepatitis
Age (yr)0.3930.0592.5990.333
Etiology, toxic6.8480.96048.8590.055
ALT (IU/L)1.0001.0001.0010.607
Bilirubin (mg/dL)1.6281.3311.991< 0.001
GWT (mm)1.1721.0241.3420.021
Ascites0.4840.1196.0390.869