Overexpression of carbonic anhydrase II and Ki-67 proteins in prognosis of gastrointestinal stromal tumors

Table 1 Pathological parameters of gastrointestinal stromal tumors in CD117, carbonic anhydrase II and Ki-67 proteins

Variable	Total	CD117		P value	CA II		P value	Ki-67		P value
		+	-		+	-		+	-
Sex
Male	61	56	5	0.317	53	8	0.515	25	36	0.171
Female	52	41	11		46	6		14	38
Age (yr)
≤ 60	61	48	13	0.036	54	7	0.485	22	39	0.859
> 60	52	49	3		45	7		17	35
Diameter
≤ 5 cm	30	27	3	0.647	25	5	0.297	8	22	0.406
> 5 cm	83	70	13		74	9		31	52
Site
Stomach	45	40	5		41	4		13	32
Small bowel	35	34	1	0.004	31	4	0.459	8	27	0.014
Others	33	23	10		27	6		18	15
Mitotic rate
≤ 5 MF/50 HPFs	52	45	7	0.941	46	6	0.515	11	41	0.009
> 5 MF/50 HPFs	61	52	9		53	8		28	33
NIH risk
Very low	5	4	1		4	1		2	3
Low	15	13	2	0.980	13	2	0.424	2	13	0.031
Medium	16	14	2		16	0		2	14
High	77	66	11		66	11		33	44
Depth of invasion
Mucosa	24	21	3		21	3		6	18
Muscular	41	33	8		38	3		10	31
Serous	30	30	0	0.033	27	3	0.168	13	17	0.013
Adjacent tissue	18	13	5		13	5		10	8

This table shows that Being compared by tumor site, mitotic rate, National Institutes of Health (NIH) risk, and depth of invasion of tumor cells, the differences were significant between the Ki-67-positive and -negative groups, while for CD117, significant differences were found for age, tumor site and depth of invasion of tumor cells. For carbonic anhydrase (CA) II, no significant differences were found between positive and negative groups. MF: Mitotic figures; HPFs: High-power fields.

Table 2 Multivariate survival analysis (Cox proportional hazards model) in gastrointestinal stromal tumors

Variable	B	Wald	df	P value	HR	95%CI for HR
						Lower	Upper
Age	0.023	1.696	1	0.193	1.024	0.988	1.060
Sex	-0.239	0.342	1	0.559	0.788	0.354	1.754
Mucosal erosion or not	1.485	2.115	1	0.146	4.416	0.597	32.684
Biopsy or not	-0.404	0.901	1	0.340	0.668	0.291	1.531
CD34	-0.071	0.086	1	0.769	0.932	0.582	1.493
CA II	-0.319	4.113	1	0.043	0.727	0.543	0.989
CD117	-0.609	4.114	1	0.042	0.544	0.303	0.978
Ki-67	1.103	7.282	1	0.007	3.014	1.352	6.717
Diameter	1.645	4.974	1	0.026	5.182	1.216	22.085
Mitotic rate	0.972	11.081	1	0.001	2.644	1.491	4.686
Site	1.334	15.581	1	0.000	3.796	1.955	7.371
Depth of invasion	0.559	7.445	1	0.006	1.748	1.170	2.612
Complete resection or not	2.807	24.674	1	0.000	16.555	5.470	50.104
Intraoperative rupture	1.937	17.997	1	0.000	0.144	0.059	0.353
Adjuvant therapy	1.757	35.579	1	0.000	5.796	3.254	10.325

This table shows that carbonic anhydrase (CA) II, CD117 and Ki-67 expression, tumor diameter, mitotic rate, tumor site, depth of invasion, complete resection, intraoperative rupture, and adjuvant therapy were important prognosis predictive factors. HR: Hazard ratios.