Endoscopic submucosal dissection for the treatment of neoplastic lesions in the gastrointestinal tract

Table 1 Mean speed of endoscopic submucosal dissection and R0 resection rate related to time

Performing ESD (yr)	Procedures (n)	Speed (min/cm2) (mean ± SD)	R0
1	10	25.5 ± 25.54	70.0%
2	17	17.6 ± 25.54	70.0%
3	22	23.4 ± 11.87	77.0%
4	32	17.4 ± 15.33	84.0%
5	22	15.1 ± 12.94	90.9%

ESD: Endoscopic submucosal dissection.

Table 2 Endoscopic submucosal dissection resection rate according to histology in esophagus and cardia, stomach and colon n (%)

	Diagnosis	Patients	En bloc	R0
Esophagus	SMT	5	5 (100.0)	3 (60.0)
	GIST	1	1 (100.0)	1 (100.0)
	Leiomyoma	4	4 (100.0)	2 (50.0)
	Non-SMT	9	9 (100.0)	6 (66.7)
	Early cancer/HGD	6	6 (100.0)	3 (50.0)
	Neoplasia grade min/med	3	3 (100.0)	3 (100.0)
Stomach	SMT	35	34 (97.1)a	27 (77.1)
	GIST	18	18 (100.0)	16 (88.9)
	Leiomyoma	6	5 (83.3)	3 (50.0)
	Other	11	11 (100.0)	8 (72.7)
	Non-SMT	19	14 (73.7)a	16 (84.2)
	Early cancer/HGD	12	8 (66.7)	10 (83.3)
	Neoplasia grade min/med	4	3 (75.0)	3 (75.0)
	Other	3	3 (100.0)	3 (100.0)
Colon	SMT	2	2 (100.0)	2 (100.0)
	Fibroepithelioma	1	1 (100.0)	1 (100.0)
	Leiomyoma	1	1 (100.0)	1 (100.0)
	Non-SMT	32	28 (87.5)	29 (90.6)
	Early cancer/HGD	19	17 (89.5)	17 (89.5)
	Neoplasia grade min/med	11	10 (90.9)	10 (90.9)
	Other	2	1 (50.0)	2 (100.0)

^aP < 0.05 vs non-submucosal tumor (SMT). GIST: Gastrointestinal stromal tumor; HGD: High grade dysplasia.

Table 3 Complications after endoscopic submucosal dissection according to location

	Patients	Delayed bleeding	Perforation	Other (n)
Cardia	14	0	1	Pneumoperitoneum	2
Stomach	54	2	5
Upper part	21	1	4	Mucosal tear of lower pharyngal sphincter region, pneumoperitoneum	3
Middle part	7	0	1
Lower part	26	1	0	Stenosis of the pylorus	2
Colon	34	0	0		0
Duodenum	1	0	0		0
All	103	2	6		7