Risk clinicopathological factors for lymph node metastasis in poorly differentiated early gastric cancer and their impact on laparoscopic wedge resection

Table 1 Univariate analysis of potential risk characteristics for lymph node metastasis n (%)

Factor	Lymph node metastasis	P value
Sex
Male (n = 60)	8 (13.3)	0.781
Female (n = 25)	4 (16.0)
Age (yr)
< 60 (n = 76)	10 (13.2)	0.534
≥ 60 (n = 9)	2 (22.2)
Family medical history
Positive (n = 3)	0 (0)	0.509
Negative (n = 82)	12 (14.6)
Number of tumors
Single (n = 83)	12 (14.5)	0.591
Multitude (n = 2)	0 (0)
Location
Upper (n = 20)	4 (20.0)	0.566
Middle (n = 5)	0 (0)
Lower (n = 60)	8 (13.3)
Tumor size in diameter
≤ 2 cm (n = 54)	3 (5.6)	0.011
> 2 cm (n = 31)	9 (29.0)
Macroscopic type
I (n = 2)	0	0.768
II (n = 64)	10 (15.6)
III (n = 19)	2 (10.5)
Depth of invasion
Mucosa (n = 56)	3 (5.4)	0.007
Submucosa (n = 29)	9 (31.0)
Lymphatic vessel involvement
Positive (n = 14)	8 (57.1)	< 0.001
Negative (n = 71)	4 (5.6)

Table 2 Multivariate analysis of potential risk factors for lymph node metastasis

Characteristics	Hazard ratio	95%CI	P value
Tumor size	7.125	1.251-38.218	0.041
≤ 2 cm
> 2 cm
Depth of invasion	16.624	1.571-82.134	0.036
Mucosa
Submucosa
Lymphatic vessel involvement	39.112	1.745-123.671	0.011
Positive
Negative