Galactosylated chitosan/5-fluorouracil nanoparticles inhibit mouse hepatic cancer growth and its side effects

Table 1 Serum levels of blood biochemical parameters in different groups by day 10

Groups	AST (U/L)	ALT (U/L)	BUN (mmol/L)	Creatinine (μmol/L)	Hbg (g/L)	PLT (×109/L)	WBC (×109/L)	Lymphocyte (×109/L)	Neutrophil (×109/L)
Control	92.79 ± 8.74	49.73 ± 4.83	23.74 ± 5.84	0.23 ± 0.09	117.32 ± 9.87	69.43 ± 8.94	6.32 ± 1.24	3.86 ± 1.34	2.18 ± 0.73
GC	92.34 ± 7.65d	49.89 ± 5.13d	23.25 ± 6.54	0.24 ± 0.08	118.823 ± 10.85	71.43 ± 6.54d	6.53 ± 1.32d	3.95 ± 1.35d	2.17 ± 0.68
5-FU	113.25 ± 7.65b	81.48 ± 6.81b	23.64 ± 5.45	0.25 ± 0.07	109.41 ± 10.73	55.63 ± 7.43a	3.83 ± 1.18b	1.57 ± 1.20a	2.75 ± 0.87
GC/5-FU	93.42 ± 8.32d	48.97 ± 4.93d	22.94 ± 5.26	0.24 ± 0.05	116.38 ± 8.53	68.64 ± 7.38c	6.21 ± 1.04d	3.81 ± 1.17c	2.17 ± 0.71
F value	8.227	33.222	0.020	0.058	0.868	4.349	5.498	4.249	0.712
P value	0.002	0.000	1.012	0.941	0.482	0.018	0.008	0.024	0.526

Data were expressed as mean ± SD. n = 5 in each group.

^aP < 0.05,

^bP < 0.01 vs control group;

^cP < 0.05,

^dP < 0.01 vs 5-fluorouracil group. AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; BUN: Blood urea nitrogen; Hbg: Hemoglobin; PLT: Platelet; WBC: White blood cell; GC: Galactosylated chitosan; 5-FU: 5-fluorouracil.