No association between IRF3 polymorphism and susceptibility to hepatitis B virus infection in Chinese patients

Table 1 Genotype and allele distributions of interferon regulatory factors tag single nucleotide polymorphisms in patients with chronic hepatitis B virus infection and with self-limiting hepatitis B virus infection n (%)

IRF3	Chronic HBV infection	Acute HBV infection	P value	OR (95% CI)
rs10415576	n = 985	n = 294
AA	347 (35.23)	119 (40.48)		1.0
GG	135 (13.71)	33 (11.22)	0.125	1.4029 (0.9091-2.1650)
AG	503 (51.07)	142 (48.30)	0.172	1.2148 (0.9187-1.6063)
A	1197 (60.76)	380 (64.63)	0.091	1.1798 (0.9740-1.4291)
G	773 (39.24)	208 (35.37)
rs2304204	n = 985	n = 294
AA	542 (55.03)	166 (56.46)
GG	54 (5.48)	14 (4.76)	0.594	1.1813 (0.6400-2.1807)
AG	389 (39.49)	114 (38.78)	0.75	1.0451 (0.7965-1.3713)
A	1473 (74.77)	446 (75.85)	0.596	1.0579 (0.8552-1.3133)
G	497 (25.23)	142 (24.15)
rs2304206	n = 985	n = 294
CC	639 (64.87)	191 (64.97)		1.0
TT	30 (3.05)	7 (2.38)	0.562	1.2810 (0.5539-2.9627)
CT	316 (32.08)	96 (32.65)	0.909	0.9839 (0.7437-1.3016)
C	1594 (80.91)	478 (81.29)	0.837	1.0250 (0.8097-1.2976)
T	376 (19.09)	110 (18.71)

IRF3: Interferon regulatory factors 3. HBV: Hepatitis B virus; OR: Odds ratio; CI: Confidence interval.

Table 2 Distribution of haplotypes of interferon regulatory factor tag single nucleotide polymorphisms rs10415576, rs2304204 and rs2304206 in patients with chronic hepatitis B virus infection and self-limiting hepatitis B virus infection

Haplotypes	Frequency(cases)	Frequency(controls)	χ2	P value	OR (95% CI)
AAC	0.6066	0.6446	2.8246	0.0929	1.1787 (0.9729-1.4279)
GAC	0.1411	0.1139	2.8473	0.0916	0.7833 (0.5895-1.0408)
GGC	0.0609	0.0527	0.5420	0.4616	0.8586 (0.5721-1.2888)
GGT	0.1904	0.1871	0.0293	0.8642	0.9796 (0.7738-1.2402)

OR: Odds ratio; CI: Confidence interval.