Health-related quality of life of 256 recipients after liver transplantation

doi:10.3748/wjg.v18.i36.5114

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Sep 28, 2012 (publication date) through Apr 18, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 28, 2012; 18(36): 5114-5121
Published online Sep 28, 2012. doi: 10.3748/wjg.v18.i36.5114

Table 1 Recipient characteristics

Factors	n (%)
Age, yr (mean ± SD, 44.57 ± 9.97)
≤ 45	151 (59)
> 45	105 (41)
Sex
Male	211 (82.4)
Female	45 (17.6)
Marital status
Married	241 (94.1)
Unmarried	3 (1.2)
Divorced/widowed	12 (4.7)
Education attainment
Elementary school	15 (5.9)
Middle school	108 (42.2)
University	133 (52)
Household income (RMB/mo)
≤ 1000	35 (13.7)
> 1000 to ≤ 3000	153 (59.8)
> 3000	68 (26.6)
Etiology disease
Hepatic cirrhosis	142 (55.5)
HCC	71 (27.7)
Severe hepatitis	30 (11.7)
Others	13 (5.1)
HCC/non-HCC	71 (27.7)/185 (72.3)
Complications (yes/no)	78 (30.5)/178 (69.5)
LT types (DDLT/LDLT)	190 (74.2)/66 (25.8)
Time since transplant
≤ 1 yr	38 (14.8)
> 1 yr, ≤ 3 yr	54 (21.1)
> 3 yr, ≤ 5 yr	66 (25.8)
> 5 yr	98 (38.3)
Employment after transplant
Full-time	83 (32.4)
Part-time	75 (29.3)
None	98 (38.3)

HCC: Hepatocellular carcinoma; DDLT: Deceased donor liver transplantation; LDLT: Living donor liver transplantation.

Table 2 Psychological outcomes after transplantation

BAI/SDS scores	Frequency	mean ± SD (%)
BAI		30.26 ± 7.44
< 45	241	94.1
≥ 45	15	5.9
SDS		0.49 ± 0.11
< 0.5	114	44.5
≥ 0.5, ≤ 0.59	104	40.6
≥ 0.6, ≤ 0.69	34	13.3
≥ 0.7	4	1.6

BAI: Beck anxiety inventory; SDS: Self-rating depression scale.

Table 3 Recipient health-related quality of life

Factors SF-36 domains	Groups (mean ± SD)	Groups (mean ± SD)	Groups (mean ± SD)	t/F value	P value
LT types	DDLT	LDLT
GH	66.86 ± 18.42	60.33 ± 16.97		t = 2.530	0.012
RP	74.47 ± 36.46	63.64 ± 42.55		t = 1.990	0.048
RE	78.95 ± 34.31	61.11 ± 44.37		t = 3.361	< 0.001
SF	88.16 ± 21.85	78.60 ± 22.76		t = 3.029	0.003
VT	75.95 ± 16.40	70.30 ± 15.76		t = 2.433	0.016
MH	71.85 ± 15.45	65.88 ± 12.94		t = 2.816	0.005
PCS	62.58 ± 6.88	60.07 ± 7.36		t = 2.507	0.013
MCS	55.95 ± 10.14	52.65 ± 7.66		t = 2.415	0.016
Age	≤ 45 yr	> 45 yr
VT	72.52 ± 16.66	77.33 ± 15.64		t = -2.332	0.020
MH	68.00 ± 14.65	73.64 ± 15.06		t = -2.995	0.003
MCS	54.05 ± 9.30	56.61 ± 10.00		t = -2.097	0.037
Complications	Yes	No
MCS	52.92 ± 12.21	56.06 ± 8.16		t = 2.412	0.017
Employment after transplant	Full-time	Part-time	None
GH	69.31 ± 18.23	63.88 ± 18.51	62.67 ± 17.63^a	F = 3.301	0.038
PF	88.67 ± 10.91	81.33 ± 17.66^a	83.32 ± 13.64^a	F = 5.809	0.003
SF	90.81 ± 20.01	85.67 ± 22.95	81.38 ± 23.28^a	F = 4.069	0.018
BP	86.02 ± 13.38	78.91 ± 19.76^a	78.76 ± 16.19^a	F = 5.331	0.005
VT	78.25 ± 15.86	72.93 ± 17.63	72.50 ± 15.45^a	F = 3.305	0.038
PCS	64.28 ± 6.20	60.87 ± 7.51^a	61.93 ± 7.08^a	F = 7.100	< 0.001

Only statistically significant data are displayed.

^aP = 0.05 vs group ”Full-time”. SF-36: Short Form-36; GH: General health; RP: Role-physical; RE: Role-emotional; SF: Social-functioning; VT: Vitality; MH: Mental health; PF: Physical functioning; BP: Bodily pain; LT: Liver transplantation; PCS: Physical component summary; MCS: Mental component summary.

Table 4 Health-related quality of life in liver recipients

SF-36 domain	LT (n = 256)	Sichuan general (n = 2249)	CHB (n = 150)	Healthy control (n = 126)	DM2 (n = 108)
General health	65.18 ± 18.25	67.30 ± 21.97	50.2 ± 24.0^a	91.23 ± 11.02^a	62.95 ± 23.87
Physical-functioning	84.47 ± 14.44	90.80 ± 15.07^a	84.5 ± 15.6	76.36 ± 26.09^a	87.38 ± 17.10^a
Role-physical	71.68 ± 38.33	79.51 ± 34.70^a	73.4 ± 27.4	82.79 ± 20.01^a	62.73 ± 39.64^a
Role-emotional	74.35 ± 37.89	76.45 ± 38.47	77.6 ± 23.8	69.46 ± 16.89	58.33 ± 43.74^a
Social-functioning	85.69 ± 22.43	85.29 ± 18.06	78.6 ± 25.8^a	74.44 ± 17.32^a	77.78 ± 25.60^a
Bodily pain	81.35 ± 16.17	82.41 ± 21.25	71.3 ± 26.0^a	85.55 ± 18.02^a	78.75 ± 25.48^a
Vitality	74.39 ± 16.41	71.44 ± 15.81^a	60.8 ± 23.6^a	75.57 ± 25.71	66.16 ± 21.66^a
Mental health	70.36 ± 15.05	73.52 ± 15.68^a	72.0 ± 20.3	73.35 ± 21.26^a	73.74 ± 21.08^a
PCS	61.93 ± 7.08	50.00 ± 10.00^a	42.8 ± 11.6^a	-	-
MCS	55.10 ± 9.66	50.00 ± 10.00^a	48.9 ± 12.3^a	-	-

Health-related quality of life (HRQoL) in liver recipients respectively compared with Sichuan general population and patients with chronic hepatitis B (CHB) or type 2 diabetes mellitus (DM2) as well as 126 healthy controls.

^aP< 0.05 vs group ”Liver transplantation (LT)”. SF-36: Short Form-36; PCS: Physical component summary; MCS: Mental component summary.

Table 5 Correlation analysis between health-related quality of life and psychological outcomes

BAI/SDS scores	PCS (SF-36)		MCS (SF-36)
BAI/SDS scores	r	P value	r	P value
BAI	-0.397	0.001	-0.401	< 0.001
SDS	-0.271	0.001	-0.239	< 0.001

BAI: Beck anxiety inventory; SDS: Self-rating depression scale; SF-36: Short Form-36; PCS: Physical component summary; MCS: Mental component summary.

Citation: Chen PX, Yan LN, Wang WT. Health-related quality of life of 256 recipients after liver transplantation. World J Gastroenterol 2012; 18(36): 5114-5121
URL: https://www.wjgnet.com/1007-9327/full/v18/i36/5114.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i36.5114