1H NMR-based serum metabolic profiling in compensated and decompensated cirrhosis

doi:10.3748/wjg.v18.i3.285

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Jan 21, 2012 (publication date) through Apr 18, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 21, 2012; 18(3): 285-290
Published online Jan 21, 2012. doi: 10.3748/wjg.v18.i3.285

Table 1 Clinical and biochemical characteristics of the cirrhotic patients and controls

		Liver cirrhosis
Parameter	Control (n = 30)	Compensated LC (n = 30)	Decompensated LC (n = 30)
Age (yr)	48.8 ± 10.5	56.3 ± 12.9	58.7 ± 14.5
Gender (M:F)	12:18	14:16	15:15
ALT (U/L)	20.4 ± 10.2	110.4 ± 20.2^a	85.4 ± 32.6^a
AST (U/L)	15.3 ± 11.6	187.5 ± 100.5^a	142.4 ± 52.9^a
TP (g/L)	65.4 ± 5.6	61.5 ± 10.2	60.4 ± 5.7^a
ALB (g/L)	50.4 ± 10.2	48.6 ± 6.9	35.8 ± 11.2^a^b
T-BIL (μmol/L)	11.4 ± 3.6	35.8 ± 30.9^a	45.6 ± 20.2^a
D-BIL (μmol/L)	5.4 ± 1.2	15.4 ± 8.3^a	23.4 ± 10.2^a^b
GLU (mmol/L)	5.31 ± 1.6	5.48 ± 1.23	5.47 ± 0.98
CRE (μmol/L)	113.6 ± 56.3	140.3 ± 50.8	152.6 ± 34.2^a
INR	1.0 ± 0.05	1.1 ± 0.06	1.2 ± 0.12
MELD score	-	12.7 ± 3.5	14.2 ± 6.3

^aP < 0.05 vs control,

^bP < 0.05 vs compensated group. Data are the number of patients or the mean ± SD.

Table 2 Orthogonal partial least-squares discriminant analysis coefficients derived from the nuclear magnetic resonance data of metabolites in serum obtained from compensated and decompensated cirrhosis patients

Metabolites	δ¹H	Correlation coefficients
		Compensated LC	Decompensated LC
β-Glucose	3.24, 4.65	0.654	0.722
α-Glucose	3.425.24	0.602	0.806
CH₃-(CH₂)n-(LDL&VLDL)	1.28	0.748	-0.693
Valine	0.99, 1.04	-0.903	-0.910
Tyrosine	6.89, 7.19	0.675	0.805
Succinate	2.40	-	0.603
Pyruvate	2.37	-	0.585
Phenylalanine	7.32, 7.41	-	0.749
NAG:N-acetyl glycoprotein	2.04	-0.583	-0.774
Lysine	1.72, 3.01, 3.78	-0.602	-
Lipid, H₃-(CH₂)n-(LDL&VLDL)	0.86	0.805	-0.793
Leucine	0.93	-0.876	-0.727
Lactate	1.33, 4.12	-0.671	-0.769
Isoleucine	0.96, 1.01	-0.916	-0.859
Histidine	7.06, 7.75	-	0.616
GPC/PC	3.21, 3.35	-0.732	-0.712
Glutamine	2.14, 2.45, 3.78	-0.659	0.706
Glutamate	2.03, 2.35, 3.78	-	0.554
Creatine	3.04, 3.93	-0.709	0.555
Citrate	2.53, 2.67	0.657	0.604
Alanine	1.48	-	0.571
Acetone	2.23	0.729	-

The positive and negative signs indicate a positive and negative correlation in the concentrations, respectively. “-”: The |correlation coefficient| is less than 0.355.

Citation: Qi SW, Tu ZG, Peng WJ, Wang LX, Ou-Yang X, Cai AJ, Dai Y. ¹H NMR-based serum metabolic profiling in compensated and decompensated cirrhosis. World J Gastroenterol 2012; 18(3): 285-290
URL: https://www.wjgnet.com/1007-9327/full/v18/i3/285.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i3.285