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©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Jul 21, 2012; 18(27): 3602-3609
Published online Jul 21, 2012. doi: 10.3748/wjg.v18.i27.3602
Published online Jul 21, 2012. doi: 10.3748/wjg.v18.i27.3602
Characteristics | Number of patients (%) | Months after surgery (mean ± SD) | P value | 1-yr survival % | 3-yr survival % | 5-yr survival % |
Age (yr) | 0.108 | |||||
< 70 | 97 (68.3) | 30 ± 17 | 91.1 | 65.3 | 40.1 | |
≥ 70 | 45 (31.7) | 27 ± 19 | 77.0 | 49.3 | 17.3 | |
Gender | 0.594 | |||||
Male | 109 (76.8) | 28 ± 17 | 71.1 | 61.1 | 23.1 | |
Female | 33 (23.2) | 30 ± 18 | 88.3 | 60.1 | 48.1 | |
Helicobacter pylori infection | 0.400 | |||||
Negative | 80 (56.3) | 30 ± 18 | 87.3 | 67.6 | 29.4 | |
Positive | 62 (43.7) | 27 ± 17 | 87.1 | 50.8 | 32.3 | |
Surgical modality | 0.950 | |||||
Partial gastrectomy | 112 (78.9) | 29 ± 18 | 85.7 | 68.6 | 35.1 | |
Total gastrectomy | 21 (14.8) | 28 ± 18 | 76.2 | 65.3 | 0.0 | |
Ivor-Lewis procedure | 9 (6.3) | 29 ± 17 | 89.2 | 60.6 | 34.3 | |
Siewert type | 0.444 | |||||
Type II | 116 (81.7) | 29 ± 17 | 86.8 | 63.8 | 27.2 | |
Type III | 26 (18.3) | 33 ± 19 | 88.5 | 50.2 | 40.2 | |
Bormann’s type | 0.380 | |||||
Polypoid | 2 (1.4) | 27 ± 26 | 100.0 | 50.1 | 50.1 | |
Fungating | 17 (12.0) | 34 ± 20 | 83.3 | 70.9 | 53.2 | |
Ulcerated | 96 (67.6) | 28 ± 17 | 88.0 | 56.3 | 26.8 | |
Flat | 27 (19.0) | 26 ± 18 | 86.5 | 66.6 | 29.6 | |
Tumor size (cm) | 0.087 | |||||
< 3 | 19 (13.4) | 30 ± 17 | 87.0 | 72.1 | 17.2 | |
3.1-7.9 | 112 (78.9) | 30 ± 17 | 89.7 | 61.5 | 38.5 | |
> 8 | 11 (7.7) | 18 ± 15 | 63.6 | 26.5 | 0.0 | |
Surgical margin | 0.165 | |||||
Negative | 126 (88.7) | 30 ± 17 | 88.8 | 60.6 | 30.1 | |
Positive | 16 (11.3) | 23 ± 19 | 74.5 | 66.2 | 33.1 | |
Lymphovascular invasion | 0.050 | |||||
Negative | 56 (39.4) | 33 ± 18 | 90.9 | 65.6 | 31.2 | |
Positive | 86 (60.6) | 27 ± 17 | 84. | 57.6 | 31.7 | |
Perineural invasion | 0.003 | |||||
Negative | 55 (38.7) | 35 ± 18 | 92.7 | 63.4 | 41.3 | |
Positive | 87 (61.3) | 26 ± 17 | 83.6 | 59.4 | 19.3 | |
Tumor differentiation | 0.0003 | |||||
Well | 1 (0.7) | 57 | 100.0 | 100.0 | 100.0 | |
Moderately | 70 (49.3) | 34 ± 17 | 95.2 | 69.3 | 44.2 | |
Poorly | 70 (49.3) | 24 ± 16 | 81.3 | 52.7 | 11.3 | |
Undifferentiated | 1 (0.7) | 4 | 0.0 | 0.0 | 0.0 | |
Tumor histopathology | 0.548 | |||||
Adenocarcinoma (nitric oxide synthase) | 112 (78.9) | 31 ± 17 | 89.6 | 71.0 | 34.2 | |
Adenocarcinoma with micropapillary feature | 24 (16.9) | 24 ± 10 | 100 | 0.0 | 0.0 | |
Adenosquamous carcinoma | 9 (6.3) | 28 ± 15 | 88.9 | 33.3 | 0.0 | |
Mucinous carcinoma | 9 (6.3) | 24 ± 14 | 88.9 | 30.5 | 30.5 | |
Signet ring cell carcinoma | 23 (16.2) | 23 ± 19 | 69.3 | 58.5 | 39.0 | |
Carcinoma with neuroendocrine features | 7 (4.9) | 28 ± 17 | 100.0 | 50.0 | 25.0 | |
Carcinoma with mixed types | 37 (26.1) | 24 ± 13 | 86.3 | 50.1 | 50.1 | |
Pathologic T stage | 0.400 | |||||
1A | 2 | 38 ± 27 | 100.0 | 50.0 | 50.0 | |
1B | 2 | 47 ± 3 | 100.0 | 100.0 | 100.0 | |
2 | 12 | 27 ± 17 | 83.3 | 72.9 | 54.7 | |
3 | 125 | 29 ± 17 | 87.0 | 59.8 | 29.2 | |
4A | 0 | 0 | - | - | - | |
4B | 1 | 18 | 100.0 | 0.0 | 0.0 | |
Pathologic N stage | 0.001 | |||||
0 | 36 | 35 ± 17 | 94.4 | 72.0 | 53.5 | |
1 | 22 | 32 ± 17 | 91.3 | 70.1 | 70.1 | |
2 | 35 | 30 ± 17 | 85.3 | 64.7 | 15.9 | |
3A | 35 | 25 ± 17 | 85.3 | 57.4 | 14.4 | |
3B | 14 | 15 ± 9 | 70.7 | 41.3 | 10.3 | |
Pathologic M stage | 0.005 | |||||
M0 | 130 | 28 ± 18 | 88.3 | 64.5 | 32.5 | |
M1 | 12 | 12 ± 4 | 75.0 | 13.1 | 13.1 | |
Overall stage | 0.012 | |||||
1A | 4 | 42 ± 16 | 100.0 | 75.0 | 75.0 | |
1B | 7 | 30 ± 15 | 100.0 | 100.0 | 100.0 | |
2A | 26 | 34 ± 19 | 88.5 | 63.0 | 42.0 | |
2B | 26 | 32 ± 17 | 84.6 | 66.8 | 60.7 | |
3A | 29 | 31 ± 17 | 93.1 | 72.6 | 19.8 | |
3B | 29 | 27 ± 18 | 86.2 | 62.9 | 15.3 | |
3C | 9 | 18 ± 10 | 76.2 | 15.2 | 15.2 | |
4 | 12 | 16 ± 9 | 75.0 | 13.1 | 13.1 |
Overall survival | |||||
Characteristic | No. of patients (%) | HR | 95% CI1 | P value | |
Celiac axis lymph node | |||||
Negative | 130 (92) | 1.00 | |||
Positive | 12 (8) | 3.33 | 1.40 | 7.95 | 0.007 |
Perineural invasion | |||||
Negative | 55 (38.7) | 1.00 | |||
Positive | 87 (61.3) | 1.48 | 0.54 | 4.11 | 0.447 |
Number of nodes retrieved/case | |||||
10 | 21 (15) | 1.00 | |||
≥ 11 | 121 (85) | 1.48 | 0.72 | 3.06 | 0.290 |
≤ 15 | 46 (32) | 1.00 | |||
≥ 16 | 96 (68) | 2.29 | 1.24 | 4.22 | 0.008 |
≤ 23 | 100 (70) | 1.00 | |||
≥ 24 | 42 (30) | 1.15 | 0.65 | 2.03 | 0.627 |
Number of positive nodes/case | |||||
≤ 6 | 58 (41) | 1.00 | |||
≥ 7 | 48 (34) | 1.72 | 1.20 | 2.46 | 0.003 |
≤ 15 | 92 (65) | 1.00 | |||
≥ 16 | 14 (10) | 2.30 | 1.40 | 3.77 | 0.001 |
Lymph node ratio | |||||
0 | 36 (25) | 1.00 | |||
≤ 0.2 | 40 (28) | 1.34 | 0.61 | 2.97 | 0.467 |
> 0.2 | 66 (46) | 2.28 | 1.15 | 4.51 | 0.018 |
Factor | No. of patients | Multivariate analysis | |||
HR | 95% CI | P value | |||
Celiac axis lymph node | Compared to pN0 | ||||
Negative | 130 | ||||
Positive | 12 | 1.76 | 0.68 | 4.57 | 0.246 |
Number of positive nodes/case | Compared to pN0 | ||||
LN+≥ 7 | 48 | 1.34 | 0.6 | 2.96 | 0.467 |
LN+≥ 16 | 14 | 2.77 | 1.15 | 4.51 | 0.018 |
Lymph node ratio | Compared to pN0 | ||||
≤ 0.2 | 40 | 3.8 | 1.28 | 11.26 | 0.016 |
> 0.2 | 66 | 7.79 | 2.05 | 29.57 | 0.003 |
Overall stage pIV | Compared to pI | ||||
12 | 18.43 | 2.27 | 145.62 | 0.002 | |
Tumor differentiation poorly differentiated | Compared to well differentiated | ||||
70 | 1.42 | 0.79 | 2.55 | 0.243 |
- Citation: Zhang YF, Shi J, Yu HP, Feng AN, Fan XS, Lauwers GY, Mashimo H, Gold JS, Chen G, Huang Q. Factors predicting survival in patients with proximal gastric carcinoma involving the esophagus. World J Gastroenterol 2012; 18(27): 3602-3609
- URL: https://www.wjgnet.com/1007-9327/full/v18/i27/3602.htm
- DOI: https://dx.doi.org/10.3748/wjg.v18.i27.3602