Review
Copyright ©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Apr 21, 2012; 18(15): 1723-1731
Published online Apr 21, 2012. doi: 10.3748/wjg.v18.i15.1723
Table 1 Cumulative rate (Cum %) of CD patients with relapsing disease during the first year and in the periods 1-5 and 5-10 years after diagnosis (Solberg et al[30], with permission)
Relapse during the 1st year
Relapse between 1-5 yr
Relapse between 5-10 yr
Variables at diagnosisTotal in each subgroupcum%(CI)P valuecum%(CI)P valuecum%(CI)P value
Age groups
A1 < 40 yr14854 (50-58)0.780 (77-83)0.661 (57-65)0.03
A2 ≥ 40 yr4951 (44-58)76 (70-82)43 (36-50)
Gender
Female9554 (49-59)0.976 (72-80)0.456 (51-61)0.9
Male10253 (48-58)81 (77-85)57 (52-62)
Location
L1: Terminal ileum5154 (47-61)0.478 (72-84)0.857 (50-64)0.1
L2: Colon9457 (52-64)76 (72-80)49 (44-54)
L3: Ileocolon4844 (37-51)81 (75-87)69 (62-76)
L4: Upper GI475 (53-97)100 (-)75 (53-97)
Behavior
B1: Inflammatory12756 (52-60)0.779 (75-83)0.654 (50-58)0.4
B2: Stricturing5049 (42-56)74 (68-78)64 (57-71)
B3: Penetrating2050 (39-61)85 (77-93)55 (44-66)
Systemic steroids
No8647 (42-52)0.0869 (64-74)0.00847 (42-52)0.02
Yes10959 (54-64)85 (82-88)63 (58-68)
Missing2---
Smoking status
Never8252 (47-57)0.579 (75-84)0.959 (54-64)0.09
Current smoker8257 (52-62)79 (75-84)61 (56-66)
Ex-smoker2945 (36-54)76 (68-84)38 (29-47)
Missing4---
Total19754 (50-57)79 (76-82)56 (53-60)
Table 2 Risk factors at diagnosis associated with surgery during follow-up analyzed by Cox regression (Solberg et al[30], with permission)
Unadjusted
Adjusted
Variables at diagnosisNumber in analysisNumber with surgery (%)HR95% CIP valueHR95% CIP value
Age
A1: < 40 yr16569 (42)1[Ref]0.031[Ref]0.03
A2: ≥ 40 yr7216 (22)0.50.3-0.90.50.3-0.9
Gender
Female11840 (34)1[Ref]0.9Not included
Male11945 (38)10.7-1.6
Location
L1: Terminal ileum6438 (59)1[Ref]< 0.0011[Ref]
L2: Isolated colonic11526 (23)0.20.1-0.40.30.2-0.60.001
L3: Ileocolon5417 (32)0.30.2-0.60.30.2-0.5< 0.001
L4: Upper GI144 (100)1.40.5-3.81.60.5-4.40.4
Behavior
B1: Inflammatory14732 (22)1[Ref]< 0.0011[Ref]
B2: Stricturing6436 (56)3.52.1-5.62.31.3-4.10.004
B3: Penetrating2617 (65)4.92.7-8.85.43.0-9.9< 0.001
Smoking status2
Never10338 (37)1[Ref]0.2Not included
Current < 10 cigarettes/d5718 (32)0.80.4-1.4
Current > 10 cigarettes/d3618 (50)1.90.8-2.6
Ex-smoker3511 (31)0.80.4-1.6
Systemic steroids3
No10636 (34)1[Ref]0.8Not included
Yes12948 (37)1.10.7-1.6