Copyright ©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Mar 21, 2012; 18(11): 1141-1153
Published online Mar 21, 2012. doi: 10.3748/wjg.v18.i11.1141
Table 1 Potential candidate genes in fatty liver disease
Category of genesExamples
Genes affecting insulin resistanceADIPOQ, AKT2, ENPP1, IRS1, PPARG, HFE, resistin
Genes affecting hepatic lipid synthesis and uptakeDGAT2, SLC25A13, ACC, ELOVL6, SCD1, GPAT, SREBP1
Genes affecting hepatic lipid uptakeAPOC3
Genes affecting hepatic triglyceride hydrolysisPNPLA2, CGI-58, LIPA
Genes affecting hepatic lipid exportAPOB, MTTP, PEMT
Genes affecting hepatic oxidative stressGCLC, NOS2, SOD2, HFE, UCP2, MAT1A, GST, GSH-Px
Genes affecting immune regulationADIPOQ, ADIPOR1, ADIPOR2, STAT3, TNFα, IL10, IL6, CTLA-4, IL-4, IL-18
Genes influencing disease progression and fibrosisTGF-β1, 3, PPARα, DDX5, CPT1A, angiotensin II
Genes influencing response to endotoxinCD14, TLR4, NOD2