Original Article
Copyright ©2011 Baishideng Publishing Group Co.
World J Gastroenterol. Feb 28, 2011; 17(8): 968-975
Published online Feb 28, 2011. doi: 10.3748/wjg.v17.i8.968
Table 1 Characteristics of control mice and CCl4-induced fibrotic mice
MouseStrainTypeSexLiver stiffness (kPa)Success rate for LSM (%)% sirius red
1C57BL/6ControlM4.775ND
2C57BL/6ControlM4.0100ND
3C57BL/6ControlM4.767ND
4C57BL/6ControlM6.886ND
5CD1ControlF5.0100< 0.3
6CD1ControlF3.3920.05
7CD1ControlF2.6940.10
8CD1Oil injectedF5.31000.42
9CD1Oil injectedF9.3840.72
10CD1Oil injectedF5.8910.32
11CD1CCl4 injectedF18.81001.84
12CD1CCl4 injectedF21.61002.36
14CD1CCl4 injectedF14.21002.38
Table 2 Characteristics of the amyloidosis group mice
MouseStrainSexLiver weight to body weight ratio (%)hapoA-II (g/L)Amyloidosis indexLS (kPa)Success rate for LSM (%)
1YF5.10.1903.990
2YMNDND09.383
3YFNDND05.9100
4YF4.40.2204.1100
5YF4.50.2204.1100
6YF4.6ND04.786
7YFNDND112.6100
8YM5.20.2303.9100
9YFNDND011.292
10KMND0.15123.7100
11KM16.00.554124.074
12KM13.80.572124.057
13KF15.80.544168.8100
14KF22.80.803168.882
15KF18.20.443168.8100
16KF12.10.42294.9100
17KF5.00.2804.496
18FM7.60.66150.2100
19FMND0.76173.0100
20FMND0.44113.592
21FF12.9ND2124.095
22FMND0.352155.5100
23FF16.30.583168.895
24FM15.70.533168.869
25FM14.90.593168.8100
26FM13.70.643124.089
27FM10.80.593168.8100
Table 3 Macroscopic liver amyloidosis index obtained by visual assessment and manual palpation
IndexLiver appearance
0Normal
1Slightly bigger and/or stiffer
2Big and stiff (± whitish zones)
3Very big and stiff, changes in the right lobe (± whitish zones)
4Very big and stiff, right lobe transformed and very big (± whitish zones)