Lamivudine resistance mutations in patients infected with hepatitis B virus genotype D

doi:10.3748/wjg.v17.i45.4987

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Dec 7, 2011 (publication date) through Apr 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 7, 2011; 17(45): 4987-4992
Published online Dec 7, 2011. doi: 10.3748/wjg.v17.i45.4987

Table 1 Demographic features of study patients

	Chronic hepatitis B	Inactive HBsAg carriers	P value
No. of patients, n (%)	245 (86.6)	38 (13.4)
Sex (male/female)	166/79	11/27	0.852
BMI (mean ± SD, kg/m²)	25.9 ± 4.3	25.7 ± 3.6	0.914
Hemoglobin (mean ± SD, gr/dL)	14.9 ± 1.5	14.9 ± 1.6	0.949
White cell count (mean ± SD, /mm³)	6577 ± 1783	6615 ± 1599	0.959
Thrombocyte count (mean ± SD, 1000/mm³)	200 482 ± 57 762	219 727 ± 63 743	0.088
AST (mean ± SD, IU/L)	56.2 ± 51.3	25.2 ± 11.1	0.000
ALT (mean ± SD, IU/L)	91.6 ± 92.6	25.3 ± 13.2	0.000
HBeAg positivity, n (%)	57 (23.2)	0
HBV DNA (mean ± SD copies/mL)	4.9 × 10⁸± 5.9 × 10⁹	2.0 × 10³± 2.6 × 10³	0.000
Histopathological findings, n¹:143
Total HAI score, median (range)	7 (1-18)
PN and BN, median (range)	2 (0-7)
ID and FN, median (range)	1 (0-4)
PI, median (range)	2 (0-4)
Fibrosis, median (range)	2 (0-4)

¹Number of patients who underwent liver biopsy. BMI: Body mass index; HAI: Histological activity index; PN: Piecemeal necrosis; BN: Bridging necrosis; ID: Intralobular degeneration; FN: Focal necrosis; PI: Portal inflammation; HBV: Hepatitis B virus; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase.

Table 2 Levels of hepatitis B virus DNA and alanine aminotransferase in chronic hepatitis B by HBeAg positivity

	HBeAg-positive (n = 57)			HBeAg-negative (n = 210)			P value
	Min	Max	mean ± SD	Min	Max	mean ± SD
ALT (IU/L)	17	537	121.6 ± 120.3	7	423	81.9 ± 77.4	0.012
HBV DNA (copies/mL)	1 × 10⁴	9.3 × 10¹⁰	1.7 × 10⁹± 1.2 × 10¹⁰	1 × 10⁴	1.4 × 10⁹	1 × 10⁸± 2.3 × 10⁸	0.15

ALT: Alanine aminotransferase; HBV: Hepatitis B virus.

Table 3 Rates of tyrosine-methionine-aspartate-aspartate mutation in patients with chronic hepatitis B virus infection n (%)

	Chronic hepatitis B			Inactive HBsAg carriers	Total
Previous lamivudine treatment		Total
Yes¹	No
YVDD + YIDD positive	17 (53.1)	Total	8 (4)	25 (10.7)	1 (3)	26 (9.7)
YMDD negative	15 (46.9)	194 (96)	209 (89.3)	32 (97)	241 (90.3)
Total	32	202	234	33	267

¹Patients who are receiving or received lamivudine previously. YMDD: Tyrosine-methionine-aspartate-aspartate; YIDD: Tyrosine-isoleucine-aspartate-aspartate; YVDD: Tyrosine-valine-aspartate-aspartate.

Citation: Yıldız O, Aygen B, Demirtürk N, Demirdal T, Inan D, Yıldırmak T, Kantürk A, Tütüncü E, Group HBS. Lamivudine resistance mutations in patients infected with hepatitis B virus genotype D. World J Gastroenterol 2011; 17(45): 4987-4992
URL: https://www.wjgnet.com/1007-9327/full/v17/i45/4987.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i45.4987