Difference between CKD-EPI and MDRD equations in calculating glomerular filtration rate in patients with cirrhosis

Table 1 Demographic and laboratory data of 3791 cirrhotic patients and 4292 common populace n (%)

Variables (n, %)	Survived cirrhotic patients(n = 2337)	Expired cirrhotic patients(n = 1454)	Common populace(n = 4292)	P value
Age (yr)	59.03 ± 14.03	63.61 ± 13.62	52.11 ± 12.13	< 0.001
Gender (male/female)	1620/717	990/464	2270/2022	< 0.001
Albumin (3.5-5 g/dL)	3.24 ± 0.68	2.48 ± 0.55	4.50 ± 0.29	< 0.001
BUN (8-12 mg/dL)	17.31 ± 14.77	60.81 ± 40.77	13.39 ± 3.78	< 0.001
Creatinine (0.4-1.2 mg/dL)	1.20 ± 1.06	2.93 ± 1.99	0.89 ± 0.20	< 0.001
eGFR (MDRD4)	79.27 ± 35.43	36.75 ± 33.55	81.72 ± 16.38	< 0.001
eGFR (MDRD6)	65.70 ± 30.28	26.76 ± 24.63	69.65 ± 13.16	< 0.001
eGFR (CKD-EPI)	78.50 ± 29.82	36.03 ± 30.23	88.31 ± 15.78	< 0.001
Total bilirubin (0.3-1.2 mg/dL)	2.24 ± 3.58	9.76 ± 10.68		< 0.001
INR	1.36 ± 0.43	2.70 ± 2.53		< 0.001
Hepatoma	647 (27.69)	717 (49.31)		< 0.001
Ascites	817 (34.96)	1018 (70.01)		< 0.001
Hepatic encephalopathy	431 (18.44)	649 (44.64)		< 0.001
Child-Pugh points	7.12 ± 1.97	10.37 ± 2.09		< 0.001

BUN: Blood urea nitrogen; eGFR: Estimated glomerular filtration rate; MDRD: Modification of Diet in Renal Disease; MDRD4: 4-variable MDRD; MDRD6: 6-variable MDRD: CKD-EPI: The Chronic Kidney Disease Epidemiology Collaboration; INR: International normalized ratio.