Ghrelin and gastrin in advanced gastric cancer before and after gastrectomy

doi:10.3748/wjg.v17.i4.449

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Jan 28, 2011 (publication date) through Apr 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 28, 2011; 17(4): 449-458
Published online Jan 28, 2011. doi: 10.3748/wjg.v17.i4.449

Table 1 Characteristics of study groups (median and range)

	*Patients with GC and H. pylori* infection (before operation)**	Patients 4-5 yr after total gastrectomy	*Controls without pathology in the gastric mucosa and H. pylori* infection**
n	25	10	25
Age (yr)	64.6 (43-81)	60.8 (49-69)	51 (22-67)
Male/female	14/11	5/5	12/13
BMI (kg/m²)	23.1 (18.7-29.7)	22.4 (20.3-24.5)	23.4 (19.5-30)

GC: Gastric cancer; H. pylori: Helicobacter pylori; BMI: Body mass index.

Table 2 Plasma ghrelin concentrations (median and range) recorded under fasting conditions and postprandially (at 60 and 90 min after a meal) in gastric cancer patients before surgery, 4-5 yr after gastrectomy, and healthy controls (95% CI) (pg/mL)

	Median fasting plasma ghrelin level	Median plasma ghrelin level 60 min postprandial	Median plasma ghrelin level 90 min postprandial
Patients GC (before surgery)	193.3¹ (150-220)	161 (125-220)	160 (153-248)
Patients 4-5 yr after gastrectomy	157² (107.1-229.4)	153.11 (108-217.3)	142 (98.4-205)
Controls	293 (179-480.4)	234 (148.3-368.4)	243.2 (151-392)

¹Indicates significant difference between fasting levels in controls and those in gastric cancer (GC) patients before surgery (P = 0.0578);

²Indicates significant difference in fasting ghrelin levels between controls and patients operated upon 4-5 years earlier (P = 0.0113).

Table 3 Plasma gastrin concentrations (median and range) in gastric cancer patients before surgery, 4-5 yr after surgery, and in healthy controls, under fasting and postprandial (60 and 90 min after a meal) conditions (95% CI) (pmol/L)

	Median fasting plasma gastrin level	Median plasma gastrin level 60 min postprandial	Median plasma gastrin level 90 min postprandial
Patients with GC (before surgery)	29 (20–43)	38 (24.5–54.2)	37 (26.4–53)
4–5 yr after gastrectomy	25.4 (14–45.5)	25.1 (14.5–43.2)	23 (13.5–39)
Controls	18.3¹² (8.4–39.5)	39 (19.1–79)	40 (20–79)

¹Indicates significant difference between control and postprandial value recorded at 60 min after a meal (P = 0.0027);

²Indicates significant difference between control and postprandial value recorded at 90 min after a meal (P = 0.0036). GC: Gastric cancer.

Citation: Zub-Pokrowiecka A, Rembiasz K, Konturek PC, Budzyński A, Konturek SJ, Winiarski M, Bielański W. Ghrelin and gastrin in advanced gastric cancer before and after gastrectomy. World J Gastroenterol 2011; 17(4): 449-458
URL: https://www.wjgnet.com/1007-9327/full/v17/i4/449.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i4.449