Down-regulation of STAT3 expression by vector-based small interfering RNA inhibits pancreatic cancer growth

Table 1 Immunochemical analyses of signal transduction and activation of transcription 3 and p-signal transduction and activation of transcription 3 expression in normal pancreatic specimens and pancreatic tumor specimens

Specimens		n	-	+	++	+++
STAT3	Normal specimens	10	9	1	0	0
	Cancer specimens	71	19	14	23	15
p-STAT3	Normal specimens	10	10	0	0	0
	Cancer specimens	71	21	11	26	13

STAT3: Signal transduction and activation of transcription 3.

Table 2 Effects of silence of signal transduction and activation of transcription 3 gene on cell cycle of pancreatic cancer cells (mean ± SD, %)

Group	G0/G1	S	G2/M
SW1990	38.76 ± 4.64	29.47 ± 3.52	31.76 ± 4.05
SW1990-Con	40.12 ± 5.12	26.53 ± 3.15	33.34 ± 4.39
SW1990-RNAi	65.39 ± 5.83a	9.88 ± 2.98a	24.73 ± 2.97

^aP < 0.05 vs control. SW1990-Con: SW1990 pRNAT-Con transfectants; SW1990-RNAi: SW1990 STAT3-RNAi transfectants.