Squamous cell carcinoma of the anus-an opportunistic cancer in HIV-positive male homosexuals

Table 1 Clinical characteristics and outcome of human immunodeficiency virus-negative patients with squamous cell carcinoma of the anus

Author	Trial	Yr	n	Male (%)	Age (range)	Local failure (%)	Overall survival
Northover et al[16]	UKCCCR	1987-1991	577	45	64 (26-88)	39	65% at 3 yr
Bartelink et al[17]	EORTC	1987-1994	103	29	60	29	69% at 3 yr
Flam et al[18]	RTOG 87-04	1987-1991	291	30	62 (29-85)	24
Ajani et al[19]	RTOG 98-11	1998-2005	644	31	55 (25-88)	25	84% at 3 yr

Table 2 Clinical characteristics and outcome of human immunodeficiency virus-positive patients with squamous cell carcinoma of the anus before the era of highly active antiretroviral therapy

Author	Yr	n	Male (%)	Age (range)	Toxicity 3-4 (%)	Local failure (%)	Overall survival
Kim et al[23]	1985-1998	13	92	42	80	61	34% at 5 yr
Holland et al[24]	1980-1993	7	100	41	100	43	29% at 2 yr
Peddada et al[25]	1987-1995	8	100	48 (37-70)	100	12	50% at 3 yr
Hoffman et al[26]	1991-1997	17			64	25
Cleator et al[27]	1989-1999	12	100	43 (30-53)	50	25	60% at 2 yr
Place et al[28]	1980-1999	14	100	42 (28-58)	50	57	20% at 5 yr
Efron et al[29]	1988-1999	6	100	40 (29-46)		67

Table 3 Clinical characteristics and outcome of human immunodeficiency virus-positive patients with squamous cell carcinoma of the anus during the era of highly active antiretroviral therapy

Author	Yr	n	Male (%)	Age (range)	Local failure (%)	Overall survival
Stadler et al[37]	1998-2002	8	100	44 (34-61)	50	67% at 2 yr
Blazy et al[38]	1997-2001	9	100	36 (35-49)	11	100% at 2 yr
Bower et al[39]	1996-2003	26	100	42 (28-56)	23	47% at 5 yr
Chiao et al[40]	1998-2004	175	99.5	49 (43-55)		66% at 4 yr
Wexler et al[41]	1997-2005	32	94	45 (31-68)	16	65% at 5 yr
Oehler-Jänne et al[42]	1997-2006	40	93	48 (34-75)	62	61% at 5 yr
Abramowitz et al[43]	1998-2004	44	100	45	32	85% at 3 yr
Seo et al[44]	1999-2007	14	93	45 (34-59)		92% at 3 yr
Barriger et al[45]	1995-2008	17	100	44 (29-53)	59	50% at 5 yr
Hogg et al[46]	1996-2006	21	100	45	48	73% at 3 yr
Fraunholz et al[47]	1997-2008	21	90	45 (31-68)	41	67% at 5 yr