Protective effects of 2,4-dihydroxybenzophenone against acetaminophen-induced hepatotoxicity in mice

Table 1 Effects of 2,4-dihydroxybenzophenone administration on malonaldehyde level and GSH/GSSG ratio in mice

Groups	MDA (μmol/g)	GSH/GSSH ratio
Control	0.30 ± 0.27	10.5 ± 2.7
Acetaminophen	0.90 ± 0.70c	7.1 ± 2.1c
BP-1 (200 mg/kg)	1.08 ± 0.68	5.1 ± 1.4a
BP-1 (400 mg/kg)	0.58 ± 0.33	6.8 ± 1.5
BP-1 (800 mg/kg)	0.50 ± 0.10	9.6 ± 1.9a

^aP < 0.05 vs acetaminophen alone group;

^cP < 0.05 vs control group. BP-1: 2,4-dihydroxybenzophenone; MDA: Malonaldehyde.