Connective tissue growth factor reacts as an IL-6/STAT3-regulated hepatic negative acute phase protein

Table 1 Mean and 95% CI for mean (in braces) of serum concentrations of interleukin-6 and connective tissue growth factor in two groups of patients with different severity of an acute phase reaction

	IL-6 (ng/L)	CTGF (μg/L)
Group 1: IL-6 < 100 ng/L (n = 21)	36 (1.7-54.3)	880.7 (344.0-1417.4)
Group 2: IL-6 ≥ 100 ng/L (n = 15)	1028.3 (46.6-2010.0)	391.2 (109.2-673.3)

IL-6: Interleukin-6; CTGF: Connective tissue growth factor.

Table 2 One sample statistics

	n	Mean CTGF (μg/L)	Std. deviation	Std. error mean
IL-6 < 100	21	851.18	900.50	196.51
IL-6 ≥ 100	15	391.23	509.36	131.52

IL-6: Interleukin-6; CTGF: Connective tissue growth factor.

Table 3 One-sample test

	Test value = 0
	t	Mean difference CTGF (μg/L)	95% CI of the difference
			Lower	Upper
IL-6 < 100	4.332	851.18	441.27	1261.08
IL-6 ≥ 100	2.975	391.23	109.15	673.30

IL-6: Interleukin-6; CTGF: Connective tissue growth factor.