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©2011 Baishideng Publishing Group Co.
World J Gastroenterol. May 14, 2011; 17(18): 2326-2331
Published online May 14, 2011. doi: 10.3748/wjg.v17.i18.2326
Published online May 14, 2011. doi: 10.3748/wjg.v17.i18.2326
Table 1 Characteristics of colorectal carcinoma cases and controls n (%)
| Parameters | Cases | Controls | P value |
| Age (mean ± SD, yr) | 57.85 ± 10.05 | 58.10 ± 13.47 | 0.751 |
| Sex | |||
| Male | 259 (54.1) | 254 (52.3) | |
| Female | 220 (45.9) | 232 (47.7) | |
| Total | 479 | 486 | 0.574 |
| Smoking status | |||
| Never | 334 (69.7) | 357 (73.5) | |
| Former | 15 (3.1) | 39 (8.0) | |
| Present | 130 (27.1) | 90 (18.5) | |
| Total | 479 | 486 | 0.199 |
| Drinking status | |||
| Never | 10 (2.1) | 16 (3.3) | |
| Former | 280 (58.5) | 207 (42.6) | |
| Present | 189 (39.5) | 263 (54.1) | |
| Total | 479 | 486 | 0.248 |
| Histological grade | |||
| High | 11 (2.3) | ||
| Intermediate | 296 (61.8) | ||
| Low | 172 (35.9) | ||
| Location | |||
| Colon | 233 (48.6) | ||
| Rectum | 242 (50.5) | ||
| Colon and rectum | 4 (0.8) | ||
| Stage | |||
| I | 142 (29.7) | ||
| II | 110 (23.0) | ||
| III | 142 (29.6) | ||
| IV | 85 (17.7) |
Table 2 Genes, polymorphism and frequencies in colorectal carcinoma cases and controls
| SNP | Genotype | Cases (n = 479) | Controls (n = 486) | Odds ratio (95% CI) | 1P value | |
| LBP | ||||||
| rs1739654 | GG | 377 (78.7%) | 360 (74.1%) | |||
| GA | 93 (19.4%) | 118 (24.3%) | 0.75 (0.55-1.02) | 0.07 | ||
| AA | 9 (1.9%) | 8 (1.6%) | 1.07 (0.41-2.82) | 0.88 | ||
| GA+AA | 102 (21.3%) | 126 (25.9%) | 0.77 (0.57-1.04) | 0.09 | ||
| rs2232596 | AA | 289 (60.3%) | 343 (70.6%) | |||
| GA | 169 (35.3%) | 133 (27.4%) | 1.51 (1.15-1.99) | 0.003 | ||
| GG | 21 (4.4%) | 10 (2%) | 2.49 (1.16-5.38) | 0.016 | ||
| GA+GG | 190 (39.7%) | 143 (29.4%) | 1.58 (1.21-2.06) | 0.001 | ||
| rs2232618 | TT | 385 (80.4%) | 396 (81.5%) | |||
| CT | 93 (19.4%) | 88 (18.1%) | 1.09 (0.79-1.50) | 0.613 | ||
| CC | 1 (0.2%) | 2 (0.4%) | 0.51 (0.05-5.70) | 0.581 | ||
| CT+CC | 94 (19.6%) | 90 (18.5%) | 1.07 (0.78-1.48) | 0.662 | ||
| CD14 | ||||||
| rs77083413 | GG | 403 (84.1%) | 400 (82.3%) | |||
| GC | 70 (14.6%) | 81 (16.7%) | 0.858 (0.605-1.215) | 0.388 | ||
| CC | 6 (1.3%) | 5 (1%) | 1.19 (0.36-3.93) | 0.774 | ||
| GC+CC | 76 (15.9%) | 86 (17.7%) | 0.88 (0.63-1.23) | 0.447 | ||
| rs4914 | CC | 369 (77%) | 415 (85.4%) | |||
| CG | 102 (21.3%) | 68 (14%) | 1.69 (1.20-2.36) | 0.002 | ||
| GG | 8 (1.7%) | 3 (0.6%) | 3.00 (0.79-11.39) | 0.091 | ||
| CG+GG | 110 (23%) | 71 (14.6%) | 1.74 (1.25-2.42) | 0.001 | ||
| IL-6 | ||||||
| rs13306435 | TT | 415 (86.6%) | 420 (86.4%) | |||
| AT | 60 (12.5%) | 65 (13.4%) | 0.93 (0.64-1.36) | 0.723 | ||
| AA | 4 (0.9%) | 1 (0.2%) | 4.05 (0.45-36.37) | 0.177 | ||
| AT+AA | 64 (13.4%) | 66 (13.6%) | 0.98 (0.68-1.42) | 0.921 |
Table 3 Stratification analyses for rs2232596 by smoking or drinking status
| Genotype frequencies (%) | Status | Cases (n = 479) | Controls (n = 486) | 1P value | Odds ratio (95% CI) |
| Smoking | |||||
| AA | No | 131 (27.3%) | 155 (31.9%) | ||
| GA | No | 59 (12.3%) | 55 (11.3%) | 0.303 | 1.26 (0.81-1.95) |
| GG | No | 10 (2.1%) | 5 (1.0%) | 0.292 | 1.86 (0.59-5.87) |
| GA/GG | No | 69 (14.4%) | 60 (12.3%) | 0.190 | 1.32 (0.87-2.02) |
| AA | Yes | 158 ( 33.0%) | 188 ( 38.7%) | ||
| GA | Yes | 100 ( 20.9%) | 78 (16.0%) | 0.005 | 1.68 (1.17-2.40) |
| GG | Yes | 11 (2.3%) | 5 (1.0%) | 0.084 | 2.59 (0.88-7.63) |
| GA/GG | Yes | 111 (23.2%) | 85 (17.0%) | 0.002 | 1.73 (1.22-2.46) |
| Drinking | |||||
| AA | No | 6 (1.3%) | 9 (1.9%) | ||
| GA | No | 4 (0.8%) | 6 (1.2%) | 0.892 | 0.89 (0.16-5.07) |
| GG | No | 0 (0%) | 1 (0.2%) | 0.998 | |
| GA/GG | No | 4 (0.8%) | 7 (1.4%) | 0.739 | 0.75 (0.14-4.03) |
| AA | Yes | 283 (59.1%) | 334 (69.7%) | ||
| GA | Yes | 165 (34.4%) | 127 (26.1%) | 0.003 | 1.53 (1.16-2.03) |
| GG | Yes | 21 (4.4%) | 9 (1.9%) | 0.015 | 2.68 (1.21-5.97) |
| GA/GG | Yes | 186 (38.8%) | 136 (28.0%) | 0.001 | 1.61 (1.23-2.11) |
Table 4 Stratification analyses for rs4914 by smoking or drinking status
| Genotype frequencies (%) | Status | Cases (n = 479) | Controls (n = 486) | 1P value | Odds ratio (95% CI) |
| Smoking | |||||
| CC | No | 146 (30.5%) | 191 (39.3%) | ||
| CG | No | 50 (10.4%) | 23 (4.7%) | 0.000 | 2.820 (1.64-4.85) |
| GG | No | 4 (0.8%) | 1 (0.2%) | 0.144 | 5.210 (0.57-47.55) |
| CG/GG | No | 54 (11.2%) | 24 (4.9%) | 0.000 | 2.920 (1.72-4.96) |
| CC | Yes | 223 (46.6%) | 224 (46.1%) | ||
| CG | Yes | 52 (10.9%) | 45 (9.3%) | 0.524 | 1.155 (0.74-1.80) |
| GG | Yes | 4 (0.8%) | 2 (0.4%) | 0.430 | 1.993 (0.36-11.05) |
| CG/GG | Yes | 56 (11.7%) | 47 (9.7%) | 0.429 | 1.190 (0.77-1.83) |
| Drinking | |||||
| CC | No | 9 (1.9%) | 10 (2.1%) | ||
| CG | No | 1 (0.2%) | 5 (1.0%) | 0.215 | 0.227 (0.02-2.37) |
| GG | No | 0 (0%) | 1 (0.2%) | 0.998 | |
| CG/GG | No | 1 (0.2%) | 6 (1.2%) | 0.154 | 0.190 (0.02-1.88) |
| CC | Yes | 360 (75.2%) | 405 (83.3%) | ||
| CG | Yes | 101 (21.1%) | 63 (13.0%) | 0.001 | 1.800 (1.28-2.55) |
| GG | Yes | 8 (1.7%) | 2 (0.4%) | 0.060 | 4.470 (0.94-21.18) |
| CG/GG | Yes | 109 (22.8%) | 65 (13.4%) | 0.000 | 1.890 (1.34-2.64) |
Table 5 Colorectal carcinoma risk with combined lipopolysaccharide binding protein rs2232596 and CD14 rs4914 SNPs
| No. of riskgenotype | Cases(n = 479) | Controls(n = 486) | 1Pvalue | Odds ratio(95% CI) |
| “0” | 235 (49.1%) | 296 (60.9%) | ||
| “1” | 194 (40.5%) | 172 (35.4%) | 0.007 | 1.46 (1.11-1.92) |
| “2” | 50 (10.4%) | 18 (3.7%) | 0.000 | 3.44 (1.94-6.10) |
| “1+2” | 244 (50.9%) | 190 (39.1%) | 0.000 | 1.66 (1.28-2.15) |
- Citation: Chen R, Luo FK, Wang YL, Tang JL, Liu YS. LBP and CD14 polymorphisms correlate with increased colorectal carcinoma risk in Han Chinese. World J Gastroenterol 2011; 17(18): 2326-2331
- URL: https://www.wjgnet.com/1007-9327/full/v17/i18/2326.htm
- DOI: https://dx.doi.org/10.3748/wjg.v17.i18.2326