Is spleen circulation impaired in systemic sclerosis and what is the role of liver fibrosis?

doi:10.3748/wjg.v17.i12.1606

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 28, 2011; 17(12): 1606-1613
Published online Mar 28, 2011. doi: 10.3748/wjg.v17.i12.1606

Table 1 Demographic, clinical and instrumental data of the population (mean ± SD)

Variables	SSc	Liver cirrhosis	Controls	P-value
The number of patients	17	18	18
Age (yr)	47.9 ± 12.6	49.7 ± 9.5	44.4 ± 9.8	0.060
Females	15	16	14	0.380¹
Type diffuse/cutaneous	12/5	ND	ND
GI involvement	9	0	ND	0.003
PAH presence	ND	3	ND
C-P score A/B	ND	12/6	ND
SLD at US (mm)	102.3 ± 9.7	130.4 ± 4.6	100.9 ± 6.6	0.000
SARI at DUS	0.56 ± 0.06	0.59 ± 0.02	0.52 ± 0.01	0.040
TE kPa	5.2 ± 1.1	ND	4.5 ± 1	0.070
NFC grade 0/1/2/3	3/7/2/5	ND	ND
Hypertension	6	0	0	0.001¹
ALT (U/L), median (range)	31 (22-41)	66.5 (36-89)	29 (22-34)	0.005
ATA/ACA/ANA positivity	3/4/2010	ND	ND

PAH: Pulmonary arterial hypertension; ATA: Anti-topoisomerase I antibodies; ACA: Anti-centromere antibodies; ANA: Anti-nuclear antibodies; GI: Gastro-intestinal motility disorders; DUS: Doppler ultrasonography; US: Ultrasonography; SLD: Spleen longitudinal diameter at US; ALT: ALanine aminoTransferase; TE: Transient elastography; NFC: Nailfold capillaroscopy; SD: Standard deviation; C-P: Child-Pugh classification; ND: Not determined;

¹: χ² for trend.

Citation: Tarantino G, Spanò A, Loi G, Parisi A, Tarantino M, Brancaccio G, Gaeta GB, Riccio A. Is spleen circulation impaired in systemic sclerosis and what is the role of liver fibrosis? World J Gastroenterol 2011; 17(12): 1606-1613
URL: https://www.wjgnet.com/1007-9327/full/v17/i12/1606.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i12.1606