Tsuzuki T, Okada H, Kawahara Y, Takenaka R, Nasu J, Ishioka H, Fujiwara A, Yoshinaga F, Yamamoto K. Proton pump inhibitor step-down therapy for GERD: A multi-center study in Japan. World J Gastroenterol 2011; 17(11): 1480-1487 [PMID: 21472108 DOI: 10.3748/wjg.v17.i11.1480]
Corresponding Author of This Article
Dr. Takao Tsuzuki, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan. takaotsuzuki@yahoo.co.jp
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Table 3 Predictors of successful step-down (univariate analysis)
Variable
ITT population(n = 83)
PP population(n = 70)
OR
P
OR
P
Age
0.984
0.428
0.965
0.212
BMI
3.667
0.073
2.108
0.251
Past history of treatment for GERD
0.497
0.161
0.228
0.019
Duration of GERD symptoms
1.004
0.416
1.199
0.536
Alcohol use
1.182
0.732
1.486
0.487
Tobacco use
1.125
0.834
0.692
0.531
Helicobacter pylori infection
0.963
0.942
1.500
0.577
Erosive esophagitis
2.599
0.062
1.402
0.620
LA classification
1.431
0.070
1.238
0.360
Atrophic gastritis
0.930
0.906
0.568
0.411
Hiatus hernia
1.333
0.566
1.476
0.545
complete remission of GERD symptoms before step-down
1.355
0.539
3.676
0.042
GSRS total score (at the beginning of step-down)
0.771
0.647
0.208
0.045
Reflux score in GSRS (at the beginning of step-down)
0.917
0.803
0.477
0.072
Indigestion score in GSRS (at the beginning of step-down)
0.594
0.209
0.218
0.011
Table 4 Predictors of successful step-down (multivariate analysis, per-protocol population: n = 70)
Variable
OR
95% CI
P
Past history of treatment for GERD
0.255
0.066-0.980
0.047
Indigestion score in GSRS (at the beginning of step down)
0.214
0.063-0.731
0.014
Citation: Tsuzuki T, Okada H, Kawahara Y, Takenaka R, Nasu J, Ishioka H, Fujiwara A, Yoshinaga F, Yamamoto K. Proton pump inhibitor step-down therapy for GERD: A multi-center study in Japan. World J Gastroenterol 2011; 17(11): 1480-1487