Anterior resection for rectal carcinoma - risk factors for anastomotic leaks and strictures

Table 1 Factors analyzed for their significance in anastomotic leaks

Factor	Leak(n = 16)	No leak(n = 92)	P value (univariate analysis)
Age (more than 60 yr)	7	13	0.011
Male sex	11	57	0.78
Distance of the tumor from	8.2	8.9	0.5
anal verge (mean, cm)
Pre- operative hemoglobin (mean, g/dL)	10	10.2	0.6
Pre- operative serum albumin (mean, g/dL)	3.6	3.5	0.4
Stapled anastomosis	6	42	0.59
Doughnut incomplete	3	2	0.032
Duration of surgery (mean, h)	1.9	2.8	0.28
Blood loss (mean, mL)	157	168	0.9
Diverting stoma	8	52	0.78
R0 resection	12	65	1
Positive resection margin	2	13	1
Mucin secreting tumour	5	28	1

¹Factors found to be significant.

Table 2 Factors analyzed for their significance in anastomotic strictures

Factor	Stricture (n = 19)	No stricture (n = 89)	P value (univariate analysis)
Age (more than 60 yr)	3	17	1
Male sex	15	53	0.126
Distance from	6.6	9.3	0.0111
anal verge (mean, cm)
Pre-operative hemoglobin (mean, gm/dL)	10.7	10.1	0.23
Pre-operative serum albumin (mean, gm/dL)	3.5	3.5	0.92
Stapled anastomosis	11	37	0.21
Doughnut incomplete	2	3	0.63
Duration of surgery (mean, h)	2.25	2.76	0.43
Blood loss (mean, mL)	177	164	0.86
Diverting stoma	11	49	1
R0 resection	15	62	0.57
Positive resection margin	2	13	0.1
Anastomotic leak	8	8	0.0011
Mucin secreting tumour	10	23	0.0291

¹Factors found to be significant.

Table 3 Significant factors determined by multivariate analysis

Factors	P value	Odds ratio
Factors affecting anastomotic leak
Advance age (> 60 yr)	0.004	7.23
Factors affecting anastomotic stricture
Anastomotic leak	0.000	13.6
Distance of growth from anal verge	0.011	6.5
Mucin secreting tumor	0.021	5.3