Brief Article
Copyright ©2010 Baishideng.
World J Gastroenterol. Mar 7, 2010; 16(9): 1138-1149
Published online Mar 7, 2010. doi: 10.3748/wjg.v16.i9.1138
Table 1 Characteristics of included studies (ITT: intention-to-treat)
Study ID (author, yr)DesignMethodsPatientsInterventionsOutcomesNotes
Jiang et al 2000[36]RCTSingle center, parallel group, not clear about the method of randomizationHistologically proved curable advanced gastric cancerD2 vs D2+Post-operative morbidity and mortality; Operation timeRegional lymph nodes were classified according to 1th English edition 1995[32]
Sano et al 2004[37] and Sasako et al 2008[39] Kodera et al 2005[38]RCTMulticenter, parallel group, computer stratified randomizationHistologically proved advanced and curable gastric cancerD2 vs D2+Post-operative morbidity and mortality; Operation time; Blood loss during operation; Five-year survival rateITT was used in result analysis; Regional lymph nodes were classified according to 1th English edition 1995[32]
Yonemura et al 2006 and 2008[40,41]RCTMulticenter, parallel group, computer randomizationYounger than 75-yr old, histologically proved advanced and curable gastric cancerD2 vs D2+Post-operative morbidity and mortality; Operation time; Blood loss during operation; Five-year survival rateSample size was calculated before trials
Kulig et al 2007[42]RCTMulticenter, parallel group, simple computer randomization.Histologically proved curable gastric adenocarcinomaD2 vs D2+Post-operative morbidity and mortality; Operation time; Blood loss during operationRegional lymph nodes were classified according to 2nd English edition 1998[31]; ITT was used in result analysis
Maeta et al 1999[43]non-RCTSingle center, parallel group, without randomizationHistologically proved advanced gastric cancer, younger than 75-yr oldD2 vs D2+Post-operative morbidity and mortality; Operation time; Blood loss during operationIn D4 group, lymph nodes (a1, a2, b1 and b2) were all removed; Sample size was smaller than that calculated before study
Bostanci et al 2004[44]non-RCTSingle center, parallel group, prospective study without randomizationHistologically proved gastric cancerD2 vs D2+Post-operative morbidity and mortality; Operation timeSurgical procedure was not very clearly described in the article
Kunisaki et al 2006[45]non-RCTMulticenter, parallel group, retrospective analysisCurable advanced gastric cancer proved by histologyD2 vs D2+Post-operative morbidity and mortality; Operation time; Blood loss during operation; Five-year survival rateData about length of post-operative hospital stay were obtained from the author
Hu et al 2009[46]non-RCTSingle center, parallel group, retrospective analysisHistologically proved curable gastric cancerD2 vs D2+Post-operative morbidity and mortality; Operation time; Five-year survival rateIn D4 group, lymph nodes (a1, a2 and b1) were dissected
Table 2 Baseline characteristics of patients in included studies
Study ID (author, yr, ND2/ND2+)Age (yr) (mean/SD or median/range)
Sex (male/female)
Pathological T stage (serosa negative/positive)
Pathological node status (negative/positive)
D2D2+PD2D2+PD2D2+PD2D2+P
Sano et al 2004[37], Sasako et al 2008[39] (263/260)60 (25-75)61(27-75)> 0.05176/87183/77> 0.05134/129146/114> 0.0579/18496/164> 0.05
Kulig et al 2007[42] (141/134)56 (31-81)54 (34-77)> 0.0585/5683/51> 0.0564/7754/84> 0.0550/9156/78> 0.05
Yonemura et al 2006 and 2008[40,41] (135/134)63.8 (9.7)62.5 (10.2)> 0.0590/4591/43> 0.0563/7261/73> 0.0537/9835/99> 0.05
Jiang et al 2000[36] (32/21)61 (46-83)65 (34-84)NR19/1311/10NRNRNRNRNRNRNR
Maeta et al 1999[43] (35/35)60 (11)59 (9)> 0.0520/1521/14> 0.052/336/29> 0.0515/2012/23> 0.05
Hu et al 2009[46] (55/62)58.8 (11.4)54.3 (11.4)< 0.0542/1348/14> 0.0513/4215/47> 0.0516/3923/39> 0.05
Kunisaki et al 2006[45] (430/150)62.2 (12.5)59.3 (10.7)> 0.05286/144109/41> 0.05197/23371/79> 0.05126/30434/116< 0.05
Bostanci et al 2004[44] (100/34)58.5 (13)59 (12.6)> 0.0563/3721/13> 0.0598/229/35NRNRNRNR
Table 3 Potential bias of included studies
Study ID (author, yr)Adequate sequence generationAllocation concealmentBlindingIncomplete outcome data addressedFree of selective reportingFree of other bias
Jiang et al 2000[36]Probably yesProbably yesProbably yesYesProbably yesProbably yes
Sano et al 2004[37], Sasako et al 2008[39]YesYesProbably yesYesProbably yesProbably yes
Yonemura et al 2006 and 2008[40,41]YesProbably yesProbably yesYesProbably yesProbably yes
Kulig et al 2007[42]YesProbably yesProbably yesYesProbably yesProbably yes
Maeta et al 1999[43]NoNoProbably yesYesProbably yesProbably yes
Bostanci et al 2004[44]NoNoProbably yesYesProbably yesProbably yes
Kunisaki et al 2006[45]NoNoProbably yesYesProbably yesProbably yes
Hu et al 2009[46]NoNoProbably yesProbably yesProbably yesProbably yes