Pegylated interferon α-2b up-regulates specific CD8+ T cells in patients with chronic hepatitis B

Table 1 Clinical characteristics of chronic hepatitis B patients included in this study

Patient	Age (yr)/sex	HBV DNA (IU/L)	ALT (U/L)	Total bilirubin (mg/dL)	Albumin (g/dL)	Platelets (× 109/L)	HBeAg	HBeAb	HBsAg	HBsAb	Genetype
1	27/M	201 000 000	143	9.1	43.7	113	+	-	+	-	C
2	25/M	160 000 000	147	12.9	47.4	167	+	+	+	-	C
3	30/M	471 000 000	205	11.9	44.3	127	+	-	+	-	C
4	21/M	32 200 000	123	10.8	45.8	181	+	-	+	-	C
5	21/M	186 000 000	148	14.2	44.1	110	+	-	+	-	C
6	38/F	30 800 000	347	18.1	45.5	126	+	-	+	-	C
7	20/F	29 000 000	171	10.0	44.9	284	+	-	+	-	C
8	20/M	143 000 000	-	13.6	48.0	248	+	-	+	-	B
9	20/F	621 000 000	112	13.4	48.5	170	+	-	+	-	C
10	23/M	597 000 000	196	18.9	43.2	201	-	+	+	-	C
11	20/F	2 910 000	98	15.6	48.0	137	+	+	+	-	C
12	38/M	63 700 000	206	11.1	51.2	142	+	+	+	-	C
13	28/M	134 000 000	138	9.0	45.9	174	+	+	+	-	C
14	25/M	237 000 000	93	16.9	51.3	130	+	-	+	-	B
15	39/M	1 190 000 000	122	18.2	50.6	166	+	-	+	-	C
16	36/M	8 820 000	170	22.9	47.1	169	+	-	+	-	C
17	25/M	655 000 000	90	20.9	46.8	161	+	-	+	-	B
18	25/M	157 000 000	164	24.3	47.3	209	-	+	+	-	C
19	20/M	290 000 000	124	11.9	47.8	140	+	-	+	-	B
20	23/M	655 000 000		19.9	44.6	194	+	-	+	-	B
21	28/M	15 300 000	237	14.5	45.3	154	+	-	+	-	C

HBV: Hepatitis B virus; ALT: Alanine aminotransferase; HBeAg: Hepatitis B e antigen; HBeAb: Hepatitis B e antibody; HBsAg: Hepatitis B surface antigen; HBsAb: Hepatitis B surface antibody.

Table 2 Predictive value of serum inducible protein-10 levels 8 wk after treatment

IP-10 (pg/mL)	ALT < 40 U/L	ALT ≥ 40 U/L	Predictive value
< 437.78	5	4	PPV = 56%
≥ 437.78	1	11	NPV = 92%

IP-10: Inducible protein-10; ALT: Alanine aminotransferase; PPV: Positive predict value; NPV: Negative predict value.