Diagnostic utility of IgG and IgM immunohistochemistry in autoimmune liver disease

Table 1 IgM/IgG ratio in PBC compared to other autoimmune liver conditions

	Sensitivity (95% CI)	Specificity (95% CI)	Likelihood ratio - positive test (95% CI)	Likelihood ratio - negative test (95% CI)	Accuracy
PBC vs AIH	92.3% (66.7-98.6)	90.0% (69.9-97.2)	9.23 (2.45-34.69)	0.085 (0.012-0.56)	90.9% (30/33)
PBC vs AIH or PSC	92.3% (66.7-98.6)	85.7% (68.5-94.3)	6.46 (2.57-16.22)	0.089 (0.013-0.59)	87.8% (36/41)
PBC vs all others	92.3% (66.7-98.6)	90.5% (77.9-96.3)	9.69 (3.76-24.94)	0.085 (0.012-0.56)	90.9% (50/55)

PBC: Primary biliary cirrhosis; AIH: Autoimmune hepatitis; PSC: Primary sclerosing cholangitis; Positive test: IgM/IgG ratio ≥ 1; Negative test: IgM/IgG ratio < 1.