Brief Article
Copyright ©2010 Baishideng Publishing Group Co.
World J Gastroenterol. Sep 21, 2010; 16(35): 4467-4475
Published online Sep 21, 2010. doi: 10.3748/wjg.v16.i35.4467
Table 1 Demographic, clinical, laboratory, metabolic and instrumental features of 224 hepatocellular carcinoma patients n (%)
VariableHCC patients (n = 224)1
Mean age (yr)54.6 ± 10.7
Male sex190 (84.8)
Liver cirrhosis122 (54.5)
Diabetes mellitus27 (12.1)
Overweight or obesitya95 (58.6)
Hypertension59 (26.3)
Body weight (kg)68.8 ± 11.0
Body heighta (cm)169.4 ± 6.4
Mean body mass indexa (kg/m2)23.9 ± 3.4
Systolic blood pressure (mmHg)128 ± 16
Diastolic blood pressure (mmHg)79 ± 9
Mean artery pressure (mmHg)95 ± 10
Past history of HBV infection173 (77.2)
Smoking99 (44.2)
Alcohol intake69 (30.8)
Positive for HBeAgb52 (26.1)
HBV-DNAc, Log105.32 ± 1.40
AFPd, > 400 ng/mL110 (50.9)
Child-Pugh Score26 (5-8)
Blood Glucose (mmol/L)5.88 ± 2.22
Total Bilirubin2 (mg/L)13 (8-23)
Albumin level (g/L)36.6 ± 6.3
International normalized ratio1.22 ± 0.24
Alanine aminotransferase2 (U/L)53 (34-83)
γ-glutamyl transferase2 (U/L)113 (58-254)
Platelet count2 (× 109/L)125 (81-183)
Triglyceridese (mmol/L)1.02 ± 0.52
Total cholesterole (mmol/L)4.27 ± 1.33
HDL cholesterolf (mmol/L)0.93 ± 0.44
LDL cholesterolf (mmol/L)2.44 ± 1.06
Creatinine2 (mg/dL)0.9 (0.8-1.0)
Blood urea nitrogen2 (mmol/L)4.98 (3.92-6.28)
Table 2 Comparison of clinical classification, clinical stage and tumor nodus metastasis stage of hepatocellular carcinoma patients with cirrhosis (n = 122) and patients without cirrhosis (n = 102) n (%)
Total patients (n = 224)Patients with LC (n = 122)Patients without LC (n = 102)P value1
Clinical classification
Massive-type134 (59.8)52 (42.6)82 (80.4)< 0.001
Nodular-type61 (27.2)49 (40.2)12 (11.8)< 0.001
Small-type15 (6.7)13 (10.7)2 (2.0)0.010
Diffuse-type14 (6.3)8 (6.6)6 (5.9)0.835
Clinical Stage
Stage I15 (6.7)9 (7.4)6 (5.9)0.656
Stage II95 (42.4)44 (36.1)51 (50.0)0.036
Stage III114 (50.9)69 (56.6)45 (44.1)0.064
TNM stage
Stage I11 (4.9)8 (6.6)3 (2.9)0.212
Stage II43 (19.2)34 (27.9)9 (8.8)< 0.001
Stage III76 (33.9)30 (24.6)46 (45.1)0.001
Stage IV94 (42.0)50 (41.0)44 (43.1)0.745
T Stage
Stage 1-281 (36.2)61 (50.0)20 (19.6)< 0.001
Stage 3-4143 (63.8)61 (50.0)82 (80.4)-
N Stage
Stage 0194 (86.6)110 (90.2)84 (82.4)0.087
Stage 130 (13.4)12 (9.8)18 (17.6)-
M stage
Stage 0130 (58.0)72 (59.0)58 (56.9)0.745
Stage 194 (42.0)50 (41.0)44 (43.1)-
Table 3 Univariate analysis of factors associated with hepatocellular carcinoma and cirrhosis n (%)
VariablePatients with LC1 (n = 122)Patients without LC1 (n = 102)P value2
Mean age (yr)54.7 ± 10.054.6 ± 11.40.909
Male sex106 (86.9)84 (82.4)0.346
Diabetes mellitus19 (15.6)8 (7.8)0.077
Overweight or obesitya54 (60.7)41 (56.2)0.562
Hypertension33 (27.0)26 (25.5)0.792
Body weight (kg)69.7 ± 11.467.7 ± 10.40.168
Body heighta (cm)169.4 ± 6.2169.5 ± 6.60.912
Mean body mass indexa (kg/m2)24.1 ± 3.623.7 ± 3.10.441
Systolic blood pressure (mmHg)128 ± 15130 ± 160.323
Diastolic blood pressure (mmHg)78 ± 979 ± 90.255
Mean artery pressure (mmHg)95 ± 1096 ± 100.243
Past history of HBV infection103 (84.4)70 (68.6)0.005
Smoking57 (46.7)42 (41.2)0.405
Alcohol intake43 (35.2)26 (25.5)0.115
Positive for HBeAgb32 (29.4)20 (22.2)0.254
HBV-DNAc, Log105.35 ± 1.375.26 ± 1.510.829
AFPd, > 400 ng/mL59 (50.9)51 (51.0)0.984
Child-Pugh Score37 (6-10)5 (5-6)< 0.001
Blood glucose (mmol/L)5.99 ± 2.445.73 ± 1.930.362
Total bilirubin3 (mg/L)17 (9-31)10 (8-17)< 0.001
Albumin level (g/L)34.8 ± 6.338.8 ± 5.6< 0.001
International normalized ratio1.31 ± 0.271.12 ± 0.15< 0.001
Alanine aminotransferase3 (U/L)58 (37-90)45 (30-81)0.050
γ glutamyl transferase3 (U/L)110 (52-257)117 (61-257)0.816
Platelet count3 (× 109/L)94 (61-152)162 (115-217)< 0.001
Triglyceridese (mmol/L)1.02 ± 0.541.02 ± 0.490.995
Total cholesterole (mmol/L)4.08 ± 1.444.53 ± 1.130.047
HDL cholesterolf (mmol/L)0.89 ± 0.480.99 ± 0.380.152
LDL cholesterolf (mmol/L)2.21 ± 1.102.78 ± 0.920.002
Creatinine3 (mg/dL)0.9 (0.8-1.0)0.9 (0.8-1.0)0.839
Blood urea nitrogen3 (mmol/L)4.95 (3.85-6.32)5.02 (3.96-6.19)0.927
Table 4 Multivariate analysis of factors associated with hepatocellular carcinoma and cirrhosis
Variable1Adjusted OR95% CIP value
Diabetes mellitus4.881.08-21.990.039
INR117.144.19-3272.280.005
Albumin level0.890.80-0.990.027
Platelet count0.9920.987-0.9970.002