p73 G4C14 to A4T14 polymorphism is associated with colorectal cancer risk and survival

Table 1 Distribution of the p73 G4C14 to A4T14 polymorphism and colorectal cancer risk n (%)

p73 genotype	Cases	Controls	OR (95% CI)1
		(n = 383)	(n = 469)
GC/GC	183 (47.8)	271 (57.8)	1.00 (reference)
GC/AT	171 (44.6)	173 (36.9)	1.46 (1.10-1.94)
AT/AT	29 (7.6)	25 (5.3)	1.72 (0.98-3.03)
GC/AT or AT/AT	200 (52.2)	198 (42.2)	1.50 (1.14-1.96)
Ptrend			0.01

¹Adjusted for age and gender.

Table 2 Stratified analysis by age and gender for the association between p73 G4C14 to A4T14 polymorphism and colorectal cancer risk

Variables	p73 genotype		Odds ratio of GC/AT + AT/AT, OR (95% CI)1
	GC/GC (case/control)	GC/AT + AT/AT (case/control)
Age (yr)
< 60	70/81	96/50	2.22 (1.39-3.55)
≥ 60	113/190	104/148	1.18 (0.84-1.66)
Gender
Male	88/153	114/104	1.91 (1.31-2.77)
Female	95/118	86/94	1.14 (0.76-1.69)

¹Adjusted for age and gender.

Table 3 The relationship between p73 protein expression and genotypes in 383 colorectal cancer patients n (%)

Genotype	Cases	p73 protein expression		P
		Positive	Negative
		(n = 252)	(n = 131)
GC/GC	183	116 (46.0)	67 (51.1)	0.09
GC/AT	171	121 (48.0)	50 (38.2)
AT/AT	29	15 (6.0)	14 (10.7)
Ptrend				0.40
GC/GC	183	116 (46.0)	67 (51.1)
GC/AT+AT/AT	200	136 (54.0)	64 (48.9)

Table 4 The relationship between p73 protein expression and clinicopathological characteristics in 383 colorectal cancer patients n (%)

Clinicopathological characteristics	No. of cases	p73 protein expression		P
		Positive	Negative
		(n = 252)	(n = 131)
Age (yr)				0.45
< 60	166	113 (68.1)	53 (31.9)
≥ 60	217	139 (64.1)	78 (35.9)
Gender				1.00
Male	203	134 (66.0)	69 (34.0)
Female	180	118 (65.6)	62 (34.4)
Histological type				0.19
Well	256	169 (66.0)	87 (34.0)
Moderate	102	64 (62.7)	38 (37.3)
Poorly	12	7 (58.3)	5 (41.7)
Mucinous	13	12 (92.3)	1 (7.7)
Invasion depth				0.003
Mucosa	3	1 (33.3)	2 (66.7)
Submucosa	9	9 (100)	0 (0)
Muscle	47	39 (83.0)	8 (17.0)
Subserosa	324	203 (62.7)	121 (37.3)
Lymph node metastasis				0.67
Positive	175	113 (64.6)	62 (35.4)
Negative	208	139 (66.8)	69 (33.2)
Dukes’ stage				0.06
A	3	1 (33.3)	2 (66.7)
B1	43	36 (83.7)	7 (16.3)
B2	162	102 (63.0)	60 (37.0)
C1	13	10 (76.9)	3 (23.1)
C2	148	92 (62.2)	56 (37.8)
D	14	11 (78.6)	3 (21.4)