Diagnosis and management of interstitial pneumonitis associated with interferon therapy for chronic hepatitis C

doi:10.3748/wjg.v16.i35.4394

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Sep 21, 2010; 16(35): 4394-4399
Published online Sep 21, 2010. doi: 10.3748/wjg.v16.i35.4394

Table 1 Case reports of interstitial pneumonitis associated with interferon therapy for hepatitis C virus

Ref.	Yr	Age (yr)/sex	Administered	Duration of IFN therapy (wk)	Diagnostic method	Treatment	Outcome
[1]	1993	60/F	IFNα-2b	8	C, R, B	D	Resolved
[2]	1994	58/F	IFN-α	12	C, R, B	D	Resolved
		56/M	IFN-α	6	C, R, B	D + S	Resolved
		72/F	IFN-α	3	C, R	D + S	Improvement
[3]	1994	48/F	IFN-α	9	C, R, B	D + S	Resolved
[4]	1994	62/F	IFN-α	3	C, R, B	D + S	Resolved
[5]	1996	49/F	IFNα-2b, Sho-saiko-to	6	C, R, B	D + S	Resolved
		59/M	IFNα-2b, Sho-saiko-to	4	C, R, B	D + S	Resolved
		42/M	IFNα-2b	16	C, R, B	D + S	Resolved
[6]	1996	46/M	IFN-α, Sho-saiko-to	4	C, R	D	Resolved
		57/M	IFN-α	5	C, R	D	Resolved
		59/M	IFN-α	23	C, R	D	Resolved
[7]	2001	57/M	IFN-α, ribavirin	12	C, R, B	D	Resolved
[8]	2002	48/F	IFNα-2b, ribavirin	24	C, R	D	Resolved
			PEGIFNα-2a, ribavirin	6	C, R, B	D + S	Improvement
		50/M	IFNα-2b, ribavirin	4	C, R, B	D + S	Resolved
[9]	2003	49/M	PEGIFNα-2b, ribavirin	2	C, R, B	D + S	Death
[10]	2004	71/F	PEGIFNα-2a, ribavirin	20	C, R, B	D	Resolved
[11]	2004	51/M	PEGIFNα-2b, ribavirin	5	C, R, B	D + S	Death
[12]	2005	58/F	PEGIFNα-2b, ribavirin	12	C, R, B	D + S	Resolved
			PEGIFNα-2a, ribavirin	12	C, R	D	Resolved
[13]	2006	68/F	IFNα-2b, ribavirin	14	C, R, B	D + S	Resolved
[14]	2007	47/F	PEGIFNα-2b, ribavirin	10	C, R, B	D + S	Resolved
[15]	2008	43/F	PEGIFNα-2b, ribavirin	48	C, R	D + S	Death
[16]	2009	39/F	PEGIFNα-2a, ribavirin	36	C, R, B	D + S	Resolved
[17]	2010	51/M	PEGIFNα-2b, ribavirin	4	C, R, B	D + S	Resolved

B: Biopsy proven diagnosis; C: Clinical diagnosis; R: Radiological diagnosis; PEGIFN-α: Pegylated interferon α; D: Discontinuation IFN-α; S: Corticosteroids therapy.

Table 2 Clinical data about patients in two subgroups

Severity of IP	Cases, n (%)	Sex (M/F)	Age (yr, mean)	Duration of IFN therapy (wk, mean)	Steroid therapy
Severe group	8 (36)	4/4	57.1	5.9	6/2
M and M group	14 (64)	7/7	52.1	14.4	9/7
P value	--	1.00	0.201¹	0.041²	0.43

¹U = 31.5, W = 109.5;

²U = 20.5, W = 53.5, P < 0.05 by Mann-Whitney test. M and M group: Mild or moderate pulmonary functional impairment group. IP: Interstitial pneumonitis; IFN: Interferon.

Citation: Ji FP, Li ZX, Deng H, Xue HA, Liu Y, Li M. Diagnosis and management of interstitial pneumonitis associated with interferon therapy for chronic hepatitis C. World J Gastroenterol 2010; 16(35): 4394-4399
URL: https://www.wjgnet.com/1007-9327/full/v16/i35/4394.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i35.4394