Brief Article
Copyright ©2010 Baishideng Publishing Group Co.
World J Gastroenterol. Sep 14, 2010; 16(34): 4348-4356
Published online Sep 14, 2010. doi: 10.3748/wjg.v16.i34.4348
Table 1 Characteristics of the studies included in the meta-analysis
IDStudyYrEthnic groupDiseasesSample size (frequency of GG allele, %)
OR (95%CI) for GG vs T alleleHardy-Weinberg equilibrium of genotype control
CaseControl
1Hancock et al[19]2008CaucasianCD594 (27.1)1024 (24.6)1.130 (0.960-1.330)0.010
2Cantó et al[20]2007CaucasianCD97 (21.7)50 (31.0)0.615 (0.357-1.060)0.147
3Henckaerts et al[21]2007CaucasianIBD1052 (24.5)280 (25.4)0.952 (0.768-1.180)0.751
CD809 (24.8)0.973 (0.780-1.214)
UC222 (22.9)0.878 (0.656-1.175)
4Van Limbergen et al[22]2007Caucasian (Scottish)IBD1079 (26.1)1233 (26.4)0.984 (0.863-1.089)0.261
CD515 (26.4)1.003 (0.850-1.182)
UC537 (26.0)0.985 (0.837-1.160)
5Van Limbergen et al[22]2007Caucasian (Swedish)IBD632 (25.3)277 (23.3)1.112 (0.880-1.406)0.741
CD244 (24.7)1.086 (0.817-1.444)
UC388 (25.5)1.129 (0.875-1.456)
6Franke et al[23]2006CaucasianIBD961 (22.4)841 (21.5)1.055 (0.900-1.235)0.958
CD633 (21.1)0.983 (0.822-1.174)
UC332 (24.4)1.181 (0.955-1.460)
7Tremelling et al[24]2006CaucasianIBD1360 (25.2)758 (25.7)0.975 (0.844-1.126)0.580
CD641 (24.9)0.964 (0.812-1.144)
UC665 (25.4)0.991 (0.837-1.173)
8McGovern et al[25]2005CaucasianIBD664 (26.6)335 (31.8)0.777 (0.634-0.952)0.195
CD358 (24.4)0.694 (0.548-0.878)
UC306 (29.1)0.880 (0.693-1.117)
Table 2 Meta-analysis of association between NOD1/CARD4 insertion/deletion polymorphism and inflammatory bowel disease
PolymorphismDiseaseSample size
nTest of association
Test of heterogeneity
CaseControlOR (95%CI)ZP valueModelχ2P valueI2(%)
GG vs TOverall12 878959680.98 (0.90-1.07)0.390.70R12.600.0844.4
CD7782959680.96 (0.86-1.07)0.780.43R14.490.0451.7
UC4900744861.01 (0.92-1.09)0.140.89F5.120.402.3
IBD onset < 401486475240.68 (0.50-0.93)2.380.02R8.300.0463.9
GG/T + GG/GG vs T/TOverall6439479881.00 (0.98-1.08)0.010.99F10.690.1534.5
CD3891479880.97 (0.86-1.10)0.420.67R12.360.0943.4
UC2450372461.00 (0.90-1.11)0.060.95F4.640.460.0
IBD onset < 40743237640.71 (0.59-0.85)3.650.0003F4.830.1837.8
GG/GG vs T/T + GG/TOverall6439479880.95 (0.81-1.11)0.620.53F12.020.1041.8
CD3891479880.91 (0.76-1.09)0.990.32F11.740.1140.4
UC2450372461.03 (0.83-1.27)0.230.81F4.890.430.0
IBD onset < 40743237640.61 (0.28-1.35)1.220.22R7.980.0562.3
GG/GG vs T/TOverall4033302080.93 (0.74-1.17)0.630.53R12.590.0844.4
CD2442302080.88 (0.68-1.14)0.960.34R12.960.0746.0
UC1623231260.97 (0.78-1.20)0.320.75F3.040.690.0
IBD onset < 40500143540.52 (0.22-1.21)1.520.13R8.840.0366.0
GG/T vs T/TOverall2816209880.95 (0.80-1.12)0.640.53F10.850.1535.5
CD1685209880.92 (0.76-1.11)0.920.36F9.940.1929.6
UC1093164861.03 (0.83-1.28)0.270.79F4.670.460.0
IBD onset < 40290111240.94 (0.64-1.37)0.330.74F5.950.1149.6
Table 3 Egger’s linear regression test to measure the funnel plot asymmetry1
ComparisonsY axle intercept: a (95%CI)
GG vs TGG/T + GG/GG vs T/TGG/GG vs T/T + GG/TGG/GG vs T/TGG/T vs T/T
Overall-1.92 (-5.57-1.72)0.96 (-2.65-4.58)2.38 (-0.87-5.64)2.38 (-1.00-5.77)2.32 (-0.71-5.36)
CD-2.62 (-6.54-1.29)1.60 (-2.38-5.59)2.79 (-0.20-5.78)2.89 (-0.31-6.09)2.51 (-0.29-5.33)
UC-0.39 (-6.54-5.75)0.57 (-5.25-6.39)-0.57 (-7.13-5.97)-0.43 (-7.00-6.13)-0.57 (-6.89-5.74)
IBD onset at < 40 yr of age-2.16 (-8.80-4.47)1.49 (-4.16-7.15)1.86 (-4.04-7.77)1.94 (-4.40-8.29)1.63 (-3.48-6.75)