Brief Article
Copyright ©2010 Baishideng.
World J Gastroenterol. Aug 21, 2010; 16(31): 3936-3943
Published online Aug 21, 2010. doi: 10.3748/wjg.v16.i31.3936
Table 1 Prevalence of different types of CagA tyrosine phosphorylation motifs compared with data obtained from Argent et al[39] and Colombian strains reports in GenBank n (%)
Type(s) of EPIYA motif
BCAABCABCABCCABCCCAABCCABABCACDTotal
Gastritis101060101019
Atrophic gastritis001550010021
Intestinal metaplasia011690000026
Duodenal ulcer001480000022
Gastric cancer011151000018
This study total1 (0.9)2 (1.9)66 (62.3)33 (31.1)1 (0.9)1 (0.9)1 (0.9)1 (0.9)0 (0.0)106
Colombian12 (2.2)2 (2.2)49 (53.3)29 (31.5)1 (1.1)2 (2.2)1 (1.1)1 (1.1)0 (0.0)87
Argent et al[39]23 (0.7)3 (0.7)262 (63.3)81 (19.6)19 (4.6)1 (0.2)1 (0.2)4 (1.0)3374
Table 2 Association between cagA Glutamine acid-Proline-Isoleucine-Tyrosine-Alanine-C motif number and gastric pathology n (%)
PathologyNo more than 1 EPIYA-C motifAt least 2 or more EPIYA-C motifOR95% CI
Gastritis12 (16.9) 7 (20)1.000-
Atrophic gastritis16 (22.5)5 (14.2)1.8670.47-7.34
Intestinal metaplasia17 (23.9)9 (25.7)1.1020.32-3.78
Duodenal ulcer14 (19.7)8 (22.8)1.0210.30-4.51
Gastric cancer12 (16.9)6 (17.1)1.1670.28-3.65
Total7135