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Copyright ©2010 Baishideng.
World J Gastroenterol. Aug 14, 2010; 16(30): 3773-3779
Published online Aug 14, 2010. doi: 10.3748/wjg.v16.i30.3773
Table 1 Medical therapy and surgery for limiting progression and causing regression of Barrett’s esophagus n (%)
PublicationNo. of patientsFollow-up (yr)AdenocarcinomaDysplasiaRegression
Medical therapy
Hillman et al[13], 20042794.77 (2.5)5 (1.8)NA
Cooper et al[9], 20061885.13 (1.6)6 (3.2)NA
Nguyen et al[14], 20092317.617 (7.4)53 (23)NA
Heath et al[10], 2007820.96 (7.3)9 (11)34 (41)
Horwhat et al[11], 2007673.82 (3.0)21 (31)13 (19)
Total8474.435 (4.1)94 (11.1)47 (31.5)
Surgery
Hofstetter et al[15], 2001795.004 (5)16 (20)
Bowers et al[16], 2002644.601 (2)31 (48)
Mabrut et al[17], 2003133.8006 (46)
Oelschlager et al[18], 2003902.61 (1)3 (3)30 (33)
Desai et al[19], 2003503.101 (2)9 (18)
O'Riordan et al[20], 2004573.82 (4)2 (4)14 (25)
Abbas et al[21], 2004331.51 (3)2 (6)13 (39)
Zaninotto et al[22], 2005352.3006 (17)
Ozmen et al[23], 2006371.601 (3)6 (16)
Biertho et al[24], 2007704.203 (4)23 (33)
Biertho et al[25], 2009234.50014 (61)
Total5513.44 (0.7)17 (3.4)168 (30.5)
Table 2 Medical therapy vs surgery for Barrett’s esophagus n (%)
PublicationTreatmentsPPINissenProgression PPIProgression NissenRegression PPIRegression NissenStudy type
Gatenby et al[6], 2009PPI vs Nissen64641154 (24)4 (10)NANACohort
Parrilla et al[28], 2003H2RA/PPI vs Nissen435810 (23)5 (9)2 (5)5 (9)RCT
Rossi et al[29], 2006PPI vs successful Nissen1916NANA12 (63)16 (100)Case comparison
Total708115164 (23.8)9 (9.1)14 (22.6)21 (28.4)