Gentiana manshurica Kitagawa prevents acetaminophen-induced acute hepatic injury in mice via inhibiting JNK/ERK MAPK pathway

Table 1 Effects of GM on hepatic damage induced by APAP in mice

Treatment	Dose (mg/kg)	Histopathological scores
		0	1	2	3	4	5	Average
Saline + Saline	-	10	0	0	0	0	0	0.0
APAP + Saline	-	0	0	1	3	4	2	3.7
APAP + GM	200	0	4	3	2	1	0	2.0b
	100	0	3	3	2	2	0	2.3a
	50	0	2	3	2	2	1	2.7
APAP + NAC	300	0	3	4	2	1	0	2.1b

APAP was given intraperitoneally with a single dose of 300 mg/kg. GM was given orally with a single dose of 200, 100 or 50 mg/kg. Livers were graded from 0 to 5 as described in Materials and Methods. Each value is the number of animals with grading changes.

^aP < 0.05,

^bP < 0.01 significantly different when compared with APAP alone group. GM: Gentiana manshurica Kitagawa; APAP: Acetaminophen.